OSA's Digital Library

Applied Spectroscopy

Applied Spectroscopy

| PUBLISHED BY SAS — AVAILABLE FROM SAS AND OSA

  • Vol. 65, Iss. 11 — Nov. 1, 2011
  • pp: 1291–1299

Characterizing the Structure of Pharmaceutical Granules Obtained by Wet Granulation with Varying Amounts of Water via Raman Chemical Imaging

Slobodan Šašić, Shannon Ingraham Loranger, and Barbara A. Johnson

Applied Spectroscopy, Vol. 65, Issue 11, pp. 1291-1299 (2011)


View Full Text Article

Acrobat PDF (1572 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

A pharmaceutical formulation containing metformin hydrochloride (MET), hydroxypropyl cellulose (HPC), and microcrystalline cellulose (MCC) was wet granulated with varying amounts of water and the structure of the obtained granules was characterized by Raman chemical mapping. Univariate Raman mapping was found to be satisfactory for producing the images of the two components of interest (HPC and MCC). In addition to the images, the average Raman spectra from the maps as well as the micro-Raman spectra from the hot pixels were analyzed. HPC is found to strongly respond to the addition of water, with its domain dissipating and Raman bands becoming weaker as the water addition increases. MCC is also responsive to water, reacting similarly to HPC but to a much smaller extent and only for the largest amounts of water. Granules made with increasing water content also have improved tabletting properties and flow.

Virtual Issues
Vol. 7, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Slobodan Šašić, Shannon Ingraham Loranger, and Barbara A. Johnson, "Characterizing the Structure of Pharmaceutical Granules Obtained by Wet Granulation with Varying Amounts of Water via Raman Chemical Imaging," Appl. Spectrosc. 65, 1291-1299 (2011)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-65-11-1291


Sort:  Journal  |  Reset

References

References are not available for this paper.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited