Eighty drugs of abuse and metabolites were successfully measured by surface-enhanced Raman spectroscopy (SERS) using gold- and silver-doped sol-gels immobilized in glass capillaries. A method was developed that provided consistent detection of 50 ppb cocaine in saliva in a focused study. This general method was successfully applied to the detection of a number of additional drugs in saliva, such as amphetamine, diazepam, and methadone.
Vol. 6, Iss. 10 Virtual Journal for Biomedical Optics
Frank Inscore, Chetan Shende, Atanu Sengupta, Hermes Huang, and Stuart Farquharson, "Detection of Drugs of Abuse in Saliva by Surface-Enhanced Raman Spectroscopy (SERS)," Appl. Spectrosc. 65, 1004-1008 (2011)