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Applied Spectroscopy

Applied Spectroscopy

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  • Vol. 66, Iss. 2 — Feb. 1, 2012
  • pp: 175–179

Chemiluminescent Identification and Quantification of Artemisinin and Relevant Sesquiterpene Lactone Derivatives

DAVID J BOWLES, ANDREW S OLSON, NEAL H. HODGES II, DANIEL L HEGLUND, ROBERTO L VARGAS, and SCOTT A WILLIAMS

Applied Spectroscopy, Vol. 66, Issue 2, pp. 175-179 (2012)


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Abstract

<b>A simple, sensitive, and rapid chemiluminescence method was developed for the detection and quantification of selected derivatives of artemisinin. It was found that the chemiluminescence (CL) signal resulting from the alkaline luminol reaction of the artemisinin derivatives in the presence of hematin was linear over a wide concentration range. We report results that suggest that a visual test or a test involving digital image capture may be used in addition to a field-ready instrumental approach to combat drug counterfeiting of malarial therapies.</b>

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Citation
DAVID J BOWLES, ANDREW S OLSON, NEAL H. HODGES II, DANIEL L HEGLUND, ROBERTO L VARGAS, and SCOTT A WILLIAMS, "Chemiluminescent Identification and Quantification of Artemisinin and Relevant Sesquiterpene Lactone Derivatives," Appl. Spectrosc. 66, 175-179 (2012)
http://www.opticsinfobase.org/as/abstract.cfm?URI=as-66-2-175


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