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Applied Spectroscopy

Applied Spectroscopy


  • Vol. 68, Iss. 1 — Jan. 1, 2014
  • pp: 124–127

Microchannel-Based Surface-Enhanced Raman Spectroscopy for Integrated Microfluidic Analysis

Chun-hong Lai, Li Chen, Gang Chen, Yi Xu, and Chun-yan Wang

Applied Spectroscopy, Vol. 68, Issue 1, pp. 124-127 (2014)

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We have demonstrated a microchannel-based, surface-enhanced Raman spectroscopy (SERS) sensing approach for integrated microfluidic analysis developed using standard micro-fabrication technology. Our approach allows high-sensitivity SERS sensing with a comparatively low-excitation optical power intensity and large cross-sectional microchannel for biological cell analysis. Utilizing a microchannel with a cross section of 100 × 70 μm2, we achieved a detection limit smaller than 10 nM for rhodamine 6G at an excitation power intensity of 132 W/cm2, avoiding any possible heating effects on the sample under investigation. There is great potential for further improvement in the sensitivity of this microchannel-based SERS detection.

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Vol. 9, Iss. 3 Virtual Journal for Biomedical Optics

Chun-hong Lai, Li Chen, Gang Chen, Yi Xu, and Chun-yan Wang, "Microchannel-Based Surface-Enhanced Raman Spectroscopy for Integrated Microfluidic Analysis," Appl. Spectrosc. 68, 124-127 (2014)

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