Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Applied Spectroscopy
  • Vol. 68,
  • Issue 3,
  • pp. 307-314
  • (2014)

Interactions Between the Antifungal Drug Myclobutanil and Gold and Silver Nanoparticles in Penicillium digitatum Investigated by Surface-Enhanced Raman Scattering

Not Accessible

Your library or personal account may give you access

Abstract

Surface-enhanced Raman scattering (SERS) of an antifungal reagent, myclobutanil (MCB), was performed on Au and Ag nanoparticles (NPs) to estimate the drug-release behaviors in fungal cells. A density functional theory (DFT) calculation was introduced to predict a favorable binding site of MCB to either the Ag or Au atom. Myclobutanil was presumed to bind more strongly to Au than to Ag in their most stable, optimized geometries of the N4 atom in its 1,2,4-triazole unit binding to the metal atom. Strong intensities were observed in the Ag SERS spectra only at acidic pH values, whereas the most prominent peaks in the Au SERS spectra of MCB matched quite well with those of 1,2,4-triazole regardless of pH conditions. The Raman spectral intensities of the MCB-assembled Ag and Au NPs decreased after treatment with either potato dextrose agar (PDA) or glutathione (GSH). Darkfield microscopy and confocal SERS were performed to analyze the MCB-assembled metal NPs inside <i>Penicillium digitatum</i> fungal cells. The results suggested that MCB was released from the metal NPs in the intracellular GSH in the fungi because we observed only fungal cell peaks.

PDF Article
More Like This
Enhanced Raman scattering of ZnO nanocrystals in the vicinity of gold and silver nanostructured surfaces

Alina Muravitskaya, Anna Rumyantseva, Sergei Kostcheev, Volodymyr Dzhagan, Oleksandr Stroyuk, and Pierre-Michel Adam
Opt. Express 24(2) A168-A173 (2016)

Surface enhanced Raman scattering of gold nanoparticles aggregated by a gold-nanofilm-coated nanofiber

Chang Cheng, Juan Li, Hongxiang Lei, and Baojun Li
Photon. Res. 6(5) 357-362 (2018)

Cited By

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved