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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 135–142

Gold nanorod light scattering labels for biomedical imaging

Le Qiu, Timothy A. Larson, Edward Vitkin, Lianyu Guo, Eugene B. Hanlon, Irving Itzkan, Konstantin V. Sokolov, and Lev T. Perelman  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 1, pp. 135-142 (2010)
http://dx.doi.org/10.1364/BOE.1.000135


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Abstract

Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting human disease through several centimeters of tissue in vivo. They have excellent biocompatibility, are non-toxic, and are not susceptible to photobleaching. They have narrow, easily tunable plasmon spectral lines and thus can image multiple molecular targets simultaneously. Because of their small size, gold nanorods can be transported to various tissues inside the human body via the vasculature and microvasculature, and since they are smaller than vascular pore sizes, they can easily cross vascular space and enter individual cells.

© 2010 OSA

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Nanotechnology and Plasmonics

History
Original Manuscript: May 27, 2010
Revised Manuscript: July 3, 2010
Manuscript Accepted: July 6, 2010
Published: July 15, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Citation
Le Qiu, Timothy A. Larson, Edward Vitkin, Lianyu Guo, Eugene B. Hanlon, Irving Itzkan, Konstantin V. Sokolov, and Lev T. Perelman, "Gold nanorod light scattering labels for biomedical imaging," Biomed. Opt. Express 1, 135-142 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-135


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References

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