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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 135–142

Gold nanorod light scattering labels for biomedical imaging

Le Qiu, Timothy A. Larson, Edward Vitkin, Lianyu Guo, Eugene B. Hanlon, Irving Itzkan, Konstantin V. Sokolov, and Lev T. Perelman  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 1, pp. 135-142 (2010)

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Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting human disease through several centimeters of tissue in vivo. They have excellent biocompatibility, are non-toxic, and are not susceptible to photobleaching. They have narrow, easily tunable plasmon spectral lines and thus can image multiple molecular targets simultaneously. Because of their small size, gold nanorods can be transported to various tissues inside the human body via the vasculature and microvasculature, and since they are smaller than vascular pore sizes, they can easily cross vascular space and enter individual cells.

© 2010 OSA

OCIS Codes
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: May 27, 2010
Revised Manuscript: July 3, 2010
Manuscript Accepted: July 6, 2010
Published: July 15, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Le Qiu, Timothy A. Larson, Edward Vitkin, Lianyu Guo, Eugene B. Hanlon, Irving Itzkan, Konstantin V. Sokolov, and Lev T. Perelman, "Gold nanorod light scattering labels for biomedical imaging," Biomed. Opt. Express 1, 135-142 (2010)

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  1. L. Qiu, T. A. Larson, D. K. Smith, E. Vitkin, S. Zhang, M. D. Modell, I. Itzkan, E. B. Hanlon, B. A. Korgel, K. V. Sokolov, and L. T. Perelman, “Single gold nanorod detection using confocal light absorption and scattering spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 13(6), 1730–1738 (2007). [CrossRef]
  2. L. Qiu, T. A. Larson, D. K. Smith, E. Vitkin, M. D. Modell, B. A. Korgel, K. V. Sokolov, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Observation of plasmon line broadening in single gold nanorods,” Appl. Phys. Lett. 93(15), 153106 (2008). [CrossRef]
  3. M. Hayat, Colloidal Gold: Principles, Methods and Applications, (Academic, San Diego, CA. 1989).
  4. U. Kreibig, and M. Vollmer, Optical Properties of Metal Clusters, (Springer-Verlag, Berlin, New York, 1995).
  5. S. Link and M. A. El-Sayed, “Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals,” Int. Rev. Phys. Chem. 19(3), 409–453 (2000). [CrossRef]
  6. P. C. Waterman, “Matrix formulation FO electromagnetic scattering,” Proc. IEEE 53, 805-& (1965).
  7. P. Debye, “Der Lichtdruck auf Kugeln von beliebigem Material,” Annalen der Physik 335(11), 57–136 (1909). [CrossRef]
  8. R. Gans, “Über die Form ultramikroskopischer Goldteilchen,” Annalen der Physik 342(5), 881–900 (1912). [CrossRef]
  9. M. Kerker, The Scattering of Light and the Other Electromagnetic Radiation, (Academic Press, New York, 1969).
  10. H. C. van de Hulst, Light Scattering by Small Particles (John Wiley & Sons, New York, 1957).
  11. M. I. Mishchenko, L. D. Travis, and D. W. Mackowski, “T-matrix computations of light scattering by nonspherical particles: A review,” J. Quant. Spectrosc. Radiat. Transf. 55(5), 535–575 (1996). [CrossRef]
  12. L. D. Landau, and E. M. Lifshitz, Electrodynamics of Continuous Media (Pergamon Press, Oxford, UK, 2nd edition, 1984).
  13. I. Itzkan, L. Qiu, H. Fang, M. M. Zaman, E. Vitkin, I. C. Ghiran, S. Salahuddin, M. Modell, C. Andersson, L. M. Kimerer, P. B. Cipolloni, K.-H. Lim, S. D. Freedman, I. Bigio, B. P. Sachs, E. B. Hanlon, and L. T. Perelman, “Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels,” Proc. Natl. Acad. Sci. U.S.A. 104(44), 17255–17260 (2007). [CrossRef] [PubMed]
  14. B. N. J. Persson, “Polarizability of small spherical metal particles: influence of the matrix environment,” Surf. Sci. 281(1-2), 153–162 (1993). [CrossRef]
  15. American National Standard for Safe Use of Lasers, ANSI Z136.1–2000. Orlando: Laser Institute of America (2000).

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