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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 157–164

Rapid spectral analysis for spectral imaging

Steven L. Jacques, Ravikant Samatham, and Niloy Choudhury  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 1, pp. 157-164 (2010)
http://dx.doi.org/10.1364/BOE.1.000157


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Abstract

Spectral imaging requires rapid analysis of spectra associated with each pixel. A rapid algorithm has been developed that uses iterative matrix inversions to solve for the absorption spectra of a tissue using a lookup table for photon pathlength based on numerical simulations. The algorithm uses tissue water content as an internal standard to specify the strength of optical scattering. An experimental example is presented on the spectroscopy of portwine stain lesions. When implemented in MATLAB, the method is ~100-fold faster than using fminsearch().

© 2010 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.0290) Scattering : Scattering
(300.0300) Spectroscopy : Spectroscopy
(300.1030) Spectroscopy : Absorption
(300.6170) Spectroscopy : Spectra

ToC Category:
Optics of Tissue and Turbid Media

History
Original Manuscript: May 5, 2010
Revised Manuscript: July 6, 2010
Manuscript Accepted: July 7, 2010
Published: July 15, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Citation
Steven L. Jacques, Ravikant Samatham, and Niloy Choudhury, "Rapid spectral analysis for spectral imaging," Biomed. Opt. Express 1, 157-164 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-157


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References

  1. S. L. Jacques and B. W. Pogue, “Tutorial on diffuse light transport,” J. Biomed. Opt. 13(4), 041302 (2008). [CrossRef] [PubMed]
  2. L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, “MCML–Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995). [CrossRef] [PubMed]
  3. K. G. Phillips and S. L. Jacques, “Solution of transport equations in layered media with refractive index mismatch using the PN-method,” J. Opt. Soc. Am. A 26(10), 2147–2162 (2009). [CrossRef] [PubMed]
  4. S. L. Jacques, Origins of tissue optical properties in the UVA, visible and NIR (1991). Optical Society of America Trends in Optics and Photonics, Vol. 2 Advances in Optical Imaging and Photon Migration, p. 364–371 (1996).
  5. C. R. Simpson, M. Kohl, M. Essenpreis, and M. Cope, “Near-infrared optical properties of ex vivo human skin and subcutaneous tissues measured using the Monte Carlo inversion technique,” Phys. Med. Biol. 43(9), 2465–2478 (1998) (as posted on website http://www.medphys.ucl.ac.uk/research/borg/research/NIR_topics/skin/ skinoptprop.htm.). [CrossRef] [PubMed]
  6. S. L. Jacques and D. J. McAuliffe, “The melanosome: threshold temperature for explosive vaporization and internal absorption coefficient during pulsed laser irradiation,” Photochem. Photobiol. 53(6), 769–775 (1991). [PubMed]

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