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Differentiating atherosclerotic plaque burden in arterial tissues using femtosecond CARS-based multimodal nonlinear optical imagingLeila B. Mostaço-Guidolin, Michael G. Sowa, Andrew Ridsdale, Adrian F. Pegoraro, Michael S. D. Smith, Mark D. Hewko, Elicia K. Kohlenberg, Bernie Schattka, Masashi Shiomi, Albert Stolow, and Alex C.-T. Ko »View Author Affiliations
Leila B. Mostaço-Guidolin,1
Michael G. Sowa,1
Andrew Ridsdale,2
Adrian F. Pegoraro,2
Michael S. D. Smith,1
Mark D. Hewko,1
Elicia K. Kohlenberg,1
Bernie Schattka,1
Masashi Shiomi,3
Albert Stolow,2
and Alex C.-T. Ko1,*
1Institute for Biodiagnostics, National Research Council Canada, Winnipeg, R3B 1Y6, Canada 2Steacie Institute for Molecular Sciences, National Research Council Canada, Ottawa, K1A 0R6, Canada 3Institute of Experimental Animals, Kobe University, School of Medicine, Kobe 650-0017, Japan *Corresponding author: alex.ko@nrc-cnrc.gc.ca |
Biomedical Optics Express, Vol. 1, Issue 1, pp. 59-73 (2010)
http://dx.doi.org/10.1364/BOE.1.000059
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Abstract
A femtosecond CARS-based nonlinear optical microscope was used to simultaneously image extracellular structural proteins and lipid-rich structures within intact aortic tissue obtained from myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits (WHHLMI). Clear differences in the NLO microscopic images were observed between healthy arterial tissue and regions dominated by atherosclerotic lesions. In the current ex-vivo study, we present a single parameter based on intensity changes derived from multi-channel NLO image to classify plaque burden within the vessel. Using this parameter we were able to differentiate between healthy regions of the vessel and regions with plaque, as well as distinguish plaques relative to the age of the WHHLMI rabbit.
© 2010 OSA
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(180.4315) Microscopy : Nonlinear microscopy
ToC Category:
Diagnostic Applications
History
Original Manuscript: May 5, 2010
Revised Manuscript: June 24, 2010
Manuscript Accepted: June 25, 2010
Published: July 14, 2010
Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express
Citation
Leila B. Mostaço-Guidolin, Michael G. Sowa, Andrew Ridsdale, Adrian F. Pegoraro, Michael S. D. Smith, Mark D. Hewko, Elicia K. Kohlenberg, Bernie Schattka, Masashi Shiomi, Albert Stolow, and Alex C.-T. Ko, "Differentiating atherosclerotic plaque burden in arterial tissues using femtosecond CARS-based multimodal nonlinear optical imaging," Biomed. Opt. Express 1, 59-73 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-59
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References
- P. Libby, “Atherosclerosis: disease biology affecting the coronary vasculature,” Am. J. Cardiol. 98(12), S3–S9 (2006). [CrossRef] [PubMed]
- G. K. Hansson, “Inflammation, atherosclerosis, and coronary artery disease,” N. Engl. J. Med. 352(16), 1685–1695 (2005). [CrossRef] [PubMed]
- A. J. Lusis, “Atherosclerosis,” Nature 407(6801), 233–241 (2000). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation 117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- P. G. Yock and P. J. Fitzgerald, “Optimal Directional Coronary Atherectomy Final Results of the Optimal Atherectomy Restenosis Study (OARS),” Am. J. Cardiol. 81, 27E–32E (1998). [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009). [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- Y. Komachi, H. Sato, and H. Tashiro, “Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease,” Appl. Opt. 45(30), 7938–7943 (2006). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003). [CrossRef] [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
- J.-X. Cheng and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications,” J. Phys. Chem. B 108(3), 827–840 (2004). [CrossRef]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express 17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
- M. Strupler, A. M. Pena, M. Hernest, P. L. Tharaux, J. L. Martin, E. Beaurepaire, and M. C. Schanne-Klein, “Second harmonic imaging and scoring of collagen in fibrotic tissues,” Opt. Express 15(7), 4054–4065 (2007). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
Achenbach, S.
Ahn, Y. C.
Anderson, K. J.
Aretz, H. T.
Balu, M.
Barlis, P.
Beaurepaire, E.
Bluemke, D. A.
Bom, N. A.
Boughner, D. R.
Bouma, B. E.
Brennan, J. F.
Brown, M. S.
Brugnera, A.
Bruschke, A. V.
Budoff, M.
Buja, L. M.
Campagnola, P. J.
Chandler, A. B.
Chang, W.-T.
Chavantes, M. C.
Chen, H.-C.
Chen, Z.
Cheng, J.-X.
Christie, R.
Costa, M. S.
Côté, D.
Courtney, B. K.
Dasari, R. R.
de Lange Davies, C.
Del Furia, F.
Denk, W.
Devries, A.
Di Mario, C.
Dick, A. J.
Dinsmore, R. E.
Evans, C. L.
Fan, J.
Fan, Z.
Feld, M. S.
Ferrante, G.
Fitzgerald, P. J.
Fitzmaurice, M.
Foster, F. S.
Fuster, V.
Galindo, L. H.
Gandhi, S. J.
Gerber, T. C.
Gersh, B.
Glagov, S.
Goldstein, J. L.
Haka, A. S.
Halpern, E. F.
Hansson, G. K.
Haugen, O. A.
Helmchen, F.
Hernest, M.
Hewko, M. D.
Hillis, L. D.
Hodgson, J. M.
Honda, Y.
Houser, S.
Hundley, W. G.
Hyman, B. T.
Iftima, N.
Insull, W.
Ito, T.
Jang, I. K.
Jhan, J.-W.
Jia, Y.
Jung, W.
Kassab, G. S.
Kawashima, S.
Kita, T.
Kloner, R. A.
Ko, A. C.-T.
Kohlenberg, E. K.
Komachi, Y.
Kramer, J. R.
La Ville, A.
Langohr, I. M.
Le, T. T.
Lesnefsky, E. J.
Leung, G.
Lewis, B.
Liau, I.
Libby, P.
Lilledahl, M. B.
Lin, C. P.
Lin, H.-L.
Liu, G.
Locker, M. J.
Loew, L. M.
Lu, B.
Lu, X.
Lusis, A. J.
MacNeill, B.
Manning, W. J.
Martin, A. A.
Martin, J. L.
McCormick, D.
Miller, A.
Moffatt, D. J.
Moselewski, F.
Mostaço-Guidolin, L. B.
Motz, J. T.
Munce, N. R.
Nair, R. N.
Nan, X.
Nikitin, A. Y.
Nogueira, G. V.
Pacheco, M. T.
Pacheco, M. T. T.
Pasqualucci, C. A.
Pegoraro, A. F.
Pena, A. M.
Pezacki, J. P.
Pickering, J. G.
Pittilo, R. M.
Pologruto, T. A.
Potma, E. O.
Printz, B. F.
Puoris’haag, M.
Puppels, G. J.
Radau, P. E.
Reddy, K. G.
Regar, E.
Ridsdale, A.
Rocha, R.
Römer, T. J.
Rosenfeld, M. E.
Rowles, P. M.
Sabatini, B. L.
Sato, H.
Schanne-Klein, M. C.
Schattka, B.
Schmitt, J. M.
Schwartz, C. J.
Schwartz, R. S.
Seddon, A. M.
Serruys, P. W.
Sheehan, H. M.
Shiomi, M.
Shishkov, M.
Silveira, L.
Smith, M. S. D.
Sowa, M. G.
Stary, H. C.
Stolow, A.
Strauss, B. H.
Strupler, M.
Stuber, M.
Sturek, M.
Su, J.
Sun, J.
Suneja, R.
Svaasand, L. O.
Svoboda, K.
Takano, M.
Tang, S.
Tashiro, H.
Tearney, G. J.
Tharaux, P. L.
Thind, A. S.
Tomov, I. V.
Tromberg, B. J.
Turner, P. R.
van der Laarse, A.
van der Steen, A. F.
van Duinen, S. G.
Villaverde, A. B.
Vitkin, I. A.
Wagner, W. D.
Wang, H.-W.
Wang, Y.
Watanabe, Y.
Webb, W. W.
Whittaker, P.
Williams, R. M.
Wissler, R. W.
Woodard, P. K.
Woolf, N.
Wright, G. A.
Wu, Y.-M.
Xie, T.
Xie, X. S.
Yamada, S.
Yang, Y.
Yeh, A.
Yock, P. G.
Yu, L.
Yu, W.
Zângaro, R. A.
Zhang, J.
Zhang, Z.
Zhou, Y.
Zipfel, W. R.
Zoumi, A.
Zwinderman, A. H.
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009). [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- J.-X. Cheng and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications,” J. Phys. Chem. B 108(3), 827–840 (2004). [CrossRef]
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005). [CrossRef] [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation 117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- P. G. Yock and P. J. Fitzgerald, “Optimal Directional Coronary Atherectomy Final Results of the Optimal Atherectomy Restenosis Study (OARS),” Am. J. Cardiol. 81, 27E–32E (1998). [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- G. K. Hansson, “Inflammation, atherosclerosis, and coronary artery disease,” N. Engl. J. Med. 352(16), 1685–1695 (2005). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation 117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- P. Libby, “Atherosclerosis: disease biology affecting the coronary vasculature,” Am. J. Cardiol. 98(12), S3–S9 (2006). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- A. J. Lusis, “Atherosclerosis,” Nature 407(6801), 233–241 (2000). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express 17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express 17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009). [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express 17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- J.-X. Cheng and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications,” J. Phys. Chem. B 108(3), 827–840 (2004). [CrossRef]
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
- P. G. Yock and P. J. Fitzgerald, “Optimal Directional Coronary Atherectomy Final Results of the Optimal Atherectomy Restenosis Study (OARS),” Am. J. Cardiol. 81, 27E–32E (1998). [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
AJR Am. J. Roentgenol.
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
Am. J. Cardiol.
- P. G. Yock and P. J. Fitzgerald, “Optimal Directional Coronary Atherectomy Final Results of the Optimal Atherectomy Restenosis Study (OARS),” Am. J. Cardiol. 81, 27E–32E (1998). [PubMed]
- P. Libby, “Atherosclerosis: disease biology affecting the coronary vasculature,” Am. J. Cardiol. 98(12), S3–S9 (2006). [CrossRef] [PubMed]
Anal. Chem.
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
Appl. Opt.
- Y. Komachi, H. Sato, and H. Tashiro, “Intravascular Raman spectroscopic catheter for molecular diagnosis of atherosclerotic coronary disease,” Appl. Opt. 45(30), 7938–7943 (2006). [CrossRef] [PubMed]
Arterioscler. Thromb. Vasc. Biol.
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
Arteriosclerosis
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
Basic Res. Cardiol.
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
Biomed. Eng. Online
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
Biophys. J.
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
Circulation
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation 117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
Eur. Heart J.
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
EuroIntervention
- P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009). [PubMed]
J. Am. Coll. Cardiol.
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
J. Atheroscler. Thromb.
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
J. Biomed. Opt.
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
J. Lipid Res.
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
J. Phys. Chem. B
- J.-X. Cheng and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications,” J. Phys. Chem. B 108(3), 827–840 (2004). [CrossRef]
Med. J. Aust.
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
N. Engl. J. Med.
- G. K. Hansson, “Inflammation, atherosclerosis, and coronary artery disease,” N. Engl. J. Med. 352(16), 1685–1695 (2005). [CrossRef] [PubMed]
Nat. Biotechnol.
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003). [CrossRef] [PubMed]
Nat. Methods
- F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005). [CrossRef] [PubMed]
Nature
- A. J. Lusis, “Atherosclerosis,” Nature 407(6801), 233–241 (2000). [CrossRef] [PubMed]
Opt. Commun.
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
Opt. Express
- A. F. Pegoraro, A. Ridsdale, D. J. Moffatt, Y. Jia, J. P. Pezacki, and A. Stolow, “Optimally chirped multimodal CARS microscopy based on a single Ti:sapphire oscillator,” Opt. Express 17(4), 2984–2996 (2009). [CrossRef] [PubMed]
- M. Balu, G. Liu, Z. Chen, B. J. Tromberg, and E. O. Potma, “Fiber delivered probe for efficient CARS imaging of tissues,” Opt. Express 18(3), 2380–2388 (2010). [CrossRef] [PubMed]
- M. Strupler, A. M. Pena, M. Hernest, P. L. Tharaux, J. L. Martin, E. Beaurepaire, and M. C. Schanne-Klein, “Second harmonic imaging and scoring of collagen in fibrotic tissues,” Opt. Express 15(7), 4054–4065 (2007). [CrossRef] [PubMed]
Opt. Lett.
- G. Liu, T. Xie, I. V. Tomov, J. Su, L. Yu, J. Zhang, B. J. Tromberg, and Z. Chen, “Rotational multiphoton endoscopy with a 1 microm fiber laser system,” Opt. Lett. 34(15), 2249–2251 (2009). [CrossRef] [PubMed]
Photomed. Laser Surg.
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
Proc. Natl. Acad. Sci. U.S.A.
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
2010, Ko, J. Biomed. Opt.
- A. C.-T. Ko, A. Ridsdale, M. S. D. Smith, L. B. Mostaço-Guidolin, M. D. Hewko, A. F. Pegoraro, E. K. Kohlenberg, B. Schattka, M. Shiomi, A. Stolow, and M. G. Sowa, “Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits,” J. Biomed. Opt. 15(2), 020501 (2010). [CrossRef] [PubMed]
- S. Tang, W. Jung, D. McCormick, T. Xie, J. Su, Y. C. Ahn, B. J. Tromberg, and Z. Chen, “Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt. 14(3), 034005 (2009). [CrossRef] [PubMed]
- H.-W. Wang, I. M. Langohr, M. Sturek, and J.-X. Cheng, “Imaging and quantitative analysis of atherosclerotic lesions by CARS-based multimodal nonlinear optical microscopy,” Arterioscler. Thromb. Vasc. Biol. 29(9), 1342–1348 (2009). [CrossRef] [PubMed]
- Y.-M. Wu, H.-C. Chen, W.-T. Chang, J.-W. Jhan, H.-L. Lin, and I. Liau, “Quantitative assessment of hepatic fat of intact liver tissues with coherent anti-stokes Raman scattering microscopy,” Anal. Chem. 81(4), 1496–1504 (2009). [CrossRef] [PubMed]
- P. Barlis and J. M. Schmitt, “Current and future developments in intracoronary optical coherence tomography imaging,” EuroIntervention 4(4), 529–533 (2009). [PubMed]
- P. Barlis, P. W. Serruys, A. Devries, and E. Regar, “Optical coherence tomography assessment of vulnerable plaque rupture: predilection for the plaque ‘shoulder’,” Eur. Heart J. 29(16), 2023 (2008). [CrossRef] [PubMed]
- P. Barlis, G. Ferrante, F. Del Furia, and C. Di Mario, “In-vivo characterisation of coronary atherosclerosis with optical coherence tomography,” Med. J. Aust. 188(12), 728 (2008). [PubMed]
- B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, G. A. Wright, and B. H. Strauss, “Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot,” Eur. Heart J. 29(5), 583–593 (2008). [CrossRef] [PubMed]
- D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, and P. K. Woodard, “Noninvasive coronary artery imaging: magnetic resonance angiography and multidetector computed tomography angiography: a scientific statement from the american heart association committee on cardiovascular imaging and intervention of the council on cardiovascular radiology and intervention, and the councils on clinical cardiology and cardiovascular disease in the young,” Circulation 118(5), 586–606 (2008). [CrossRef] [PubMed]
- Y. Honda and P. J. Fitzgerald, “Frontiers in intravascular imaging technologies,” Circulation 117(15), 2024–2037 (2008). [CrossRef] [PubMed]
- J. Sun, Z. Zhang, B. Lu, W. Yu, Y. Yang, Y. Zhou, Y. Wang, and Z. Fan, “Identification and quantification of coronary atherosclerotic plaques: a comparison of 64-MDCT and intravascular ultrasound,” AJR Am. J. Roentgenol. 190(3), 748–754 (2008). [CrossRef] [PubMed]
- H.-W. Wang, T. T. Le, and J.-X. Cheng, “Label-free imaging of arterial cells and extracellular matrix using a multimodal CARS microscope,” Opt. Commun. 281(7), 1813–1822 (2008). [CrossRef] [PubMed]
- T. T. Le, I. M. Langohr, M. J. Locker, M. Sturek, and J.-X. Cheng, “Label-free molecular imaging of atherosclerotic lesions using multimodal nonlinear optical microscopy,” J. Biomed. Opt. 12(5), 054007 (2007). [CrossRef] [PubMed]
- M. B. Lilledahl, O. A. Haugen, C. de Lange Davies, and L. O. Svaasand, “Characterization of vulnerable plaques by multiphoton microscopy,” J. Biomed. Opt. 12(4), 044005 (2007). [CrossRef] [PubMed]
- R. Rocha, L. Silveira, A. B. Villaverde, C. A. Pasqualucci, M. S. Costa, A. Brugnera, and M. T. T. Pacheco, “Use of near-infrared Raman spectroscopy for identification of atherosclerotic plaques in the carotid artery,” Photomed. Laser Surg. 25(6), 482–486 (2007). [CrossRef] [PubMed]
- J. T. Motz, M. Fitzmaurice, A. Miller, S. J. Gandhi, A. S. Haka, L. H. Galindo, R. R. Dasari, J. R. Kramer, and M. S. Feld, “In vivo Raman spectral pathology of human atherosclerosis and vulnerable plaque,” J. Biomed. Opt. 11(2), 021003 (2006). [CrossRef] [PubMed]
- P. Libby, “Atherosclerosis: disease biology affecting the coronary vasculature,” Am. J. Cardiol. 98(12), S3–S9 (2006). [CrossRef] [PubMed]
- G. K. Hansson, “Inflammation, atherosclerosis, and coronary artery disease,” N. Engl. J. Med. 352(16), 1685–1695 (2005). [CrossRef] [PubMed]
- G. V. Nogueira, L. Silveira, A. A. Martin, R. A. Zângaro, M. T. Pacheco, M. C. Chavantes, and C. A. Pasqualucci, “Raman spectroscopy study of atherosclerosis in human carotid artery,” J. Biomed. Opt. 10(3), 031117 (2005). [CrossRef] [PubMed]
- I. K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography,” Circulation 111(12), 1551–1555 (2005). [CrossRef] [PubMed]
- C. L. Evans, E. O. Potma, M. Puoris’haag, D. Côté, C. P. Lin, and X. S. Xie, “Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy,” Proc. Natl. Acad. Sci. U.S.A. 102(46), 16807–16812 (2005). [CrossRef] [PubMed]
- F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005). [CrossRef] [PubMed]
- R. M. Williams, W. R. Zipfel, and W. W. Webb, “Interpreting second-harmonic generation images of collagen I fibrils,” Biophys. J. 88(2), 1377–1386 (2005). [CrossRef] [PubMed]
- A. Zoumi, X. Lu, G. S. Kassab, and B. J. Tromberg, “Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopy,” Biophys. J. 87(4), 2778–2786 (2004). [CrossRef] [PubMed]
- J.-X. Cheng and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Instrumentation, Theory, and Applications,” J. Phys. Chem. B 108(3), 827–840 (2004). [CrossRef]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Correlation of vulnerable coronary plaques to sudden cardiac events. Lessons from a myocardial infarction-prone animal model (the WHHLMI rabbit),” J. Atheroscler. Thromb. 11(4), 184–189 (2004). [PubMed]
- M. Shiomi, T. Ito, S. Yamada, S. Kawashima, and J. Fan, “Development of an animal model for spontaneous myocardial infarction (WHHLMI rabbit),” Arterioscler. Thromb. Vasc. Biol. 23(7), 1239–1244 (2003). [CrossRef] [PubMed]
- T. A. Pologruto, B. L. Sabatini, and K. Svoboda, “ScanImage: flexible software for operating laser scanning microscopes,” Biomed. Eng. Online 2(1), 13 (2003). [CrossRef] [PubMed]
- X. Nan, J.-X. Cheng, and X. S. Xie, “Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy,” J. Lipid Res. 44(11), 2202–2208 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, “Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation,” Proc. Natl. Acad. Sci. U.S.A. 100(12), 7075–7080 (2003). [CrossRef] [PubMed]
- P. J. Campagnola and L. M. Loew, “Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms,” Nat. Biotechnol. 21(11), 1356–1360 (2003). [CrossRef] [PubMed]
- W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003). [CrossRef] [PubMed]
- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A. 99(17), 11014–11019 (2002). [CrossRef] [PubMed]
- A. J. Lusis, “Atherosclerosis,” Nature 407(6801), 233–241 (2000). [CrossRef] [PubMed]
- T. J. Römer, J. F. Brennan, G. J. Puppels, A. H. Zwinderman, S. G. van Duinen, A. van der Laarse, A. F. van der Steen, N. A. Bom, and A. V. Bruschke, “Intravascular ultrasound combined with Raman spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries,” Arterioscler. Thromb. Vasc. Biol. 20(2), 478–483 (2000). [PubMed]
- P. G. Yock and P. J. Fitzgerald, “Optimal Directional Coronary Atherectomy Final Results of the Optimal Atherectomy Restenosis Study (OARS),” Am. J. Cardiol. 81, 27E–32E (1998). [PubMed]
- H. C. Stary, A. B. Chandler, R. E. Dinsmore, V. Fuster, S. Glagov, W. Insull, M. E. Rosenfeld, C. J. Schwartz, W. D. Wagner, and R. W. Wissler, “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association,” Circulation 92(5), 1355–1374 (1995). [PubMed]
- P. Whittaker, R. A. Kloner, D. R. Boughner, and J. G. Pickering, “Quantitative assessment of myocardial collagen with picrosirius red staining and circularly polarized light,” Basic Res. Cardiol. 89(5), 397–410 (1994). [CrossRef] [PubMed]
- J. M. Hodgson, K. G. Reddy, R. Suneja, R. N. Nair, E. J. Lesnefsky, and H. M. Sheehan, “Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty,” J. Am. Coll. Cardiol. 21(1), 35–44 (1993). [CrossRef] [PubMed]
- A. M. Seddon, N. Woolf, A. La Ville, R. M. Pittilo, P. M. Rowles, P. R. Turner, and B. Lewis, “Hereditary hyperlipidemia and atherosclerosis in the rabbit due to overproduction of lipoproteins. II. Preliminary report of arterial pathology,” Arteriosclerosis 7(2), 113–124 (1987). [PubMed]
- L. M. Buja, T. Kita, J. L. Goldstein, Y. Watanabe, and M. S. Brown, “Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia,” Arteriosclerosis 3(1), 87–101 (1983). [PubMed]
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