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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 11 — Nov. 1, 2011
  • pp: 2961–2972

Double-clad fiber with a tapered end for confocal endomicroscopy

Simon Lemire-Renaud, Mathias Strupler, Fouzi Benboujja, Nicolas Godbout, and Caroline Boudoux  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 11, pp. 2961-2972 (2011)

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We present a double-clad fiber coupler (DCFC) for use in confocal endomicroscopy to reduce speckle contrast, increase signal collection while preserving optical sectioning. The DCFC is made by incorporating a double-clad tapered fiber (DCTF) to a fused-tapered DCFC for achromatic transmission (from 1265 nm to 1325 nm) of > 95% illumination light trough the single mode (SM) core and collection of > 40% diffuse light through inner cladding modes. Its potential for confocal endomicroscopy is demonstrated in a spectrally-encoded imaging setup which shows a 3 times reduction in speckle contrast as well as 5.5 × increase in signal collection compared to imaging with a SM fiber.

© 2011 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(060.2340) Fiber optics and optical communications : Fiber optics components
(110.2990) Imaging systems : Image formation theory
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2150) Medical optics and biotechnology : Endoscopic imaging

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: July 5, 2011
Revised Manuscript: August 10, 2011
Manuscript Accepted: August 25, 2011
Published: October 3, 2011

Simon Lemire-Renaud, Mathias Strupler, Fouzi Benboujja, Nicolas Godbout, and Caroline Boudoux, "Double-clad fiber with a tapered end for confocal endomicroscopy," Biomed. Opt. Express 2, 2961-2972 (2011)

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  1. R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127, 706–713 (2004). [CrossRef] [PubMed]
  2. A. M. Buchner, M. W. Shahid, M. G. Heckman, M. Krishna, M. Ghabril, M. Hasan, J. E. Crook, V. Gomez, M. Raimondo, T. Woodward, H. C. Wolfsen, and M. B. Wallace, “Comparison of probe-based confocal laser endomicroscopy with virtual chromoendoscopy for classification of colon polyps,” Gastroenterology138, 834–842 (2010). [CrossRef]
  3. H. Neumann, R. Kiesslich, M. B. Wallace, and M. F. Neurath, “Confocal laser endomicroscopy: technical advances and clinical applications,” Gastroenterology139, 388–392 (2010). [CrossRef] [PubMed]
  4. K. Carlson, I. Pavlova, T. Collier, M. Descour, M. Follen, and R. Richards-Kortum, “Confocal microscopy: Imaging cervical precancerous lesions,” Gynecologic Oncology99, S84–S88 (2005), The 4th International Conference on Cervical Cancer with a Day of Spiritual, Psychological, Complementary, and Alternative Treatment of Cancer and Pain. [CrossRef] [PubMed]
  5. B. Luck, K. Carlson, A. Bovik, and R. Richards-Kortum, “An image model and segmentation algorithm for reflectance confocal images of in vivo cervical tissue,” IEEE Trans. Image Process.14, 1265–1276 (2005). [CrossRef] [PubMed]
  6. B. Farahati, O. Stachs, F. Prall, J. Stave, R. Guthoff, H. W. Pau, and T. Just, “Rigid confocal endoscopy for in vivo imaging of experimental oral squamous intra-epithelial lesions,” J. Oral. Pathol. Med.39, 318–327 (2010). [PubMed]
  7. L. Thiberville, M. Salan, S. Lachkar, S. Dominique, S. Moreno-Swirc, C. Vever-Bizet, and G. Bourg-Heckly, “Confocal fluorescence endomicroscopy of the human airways.” Proceedings of the American Thoracic Society6, 444 – 449 (2009). [CrossRef] [PubMed]
  8. P. M. Lane, “Terminal reflections in fiber-optic image guides,” Appl. Opt.48, 5802–5810 (2009). [CrossRef] [PubMed]
  9. M. Merman, A. Abramov, and D. Yelin, “Theoretical analysis of spectrally encoded endoscopy,” Opt. Express17, 24045–24059 (2009). [CrossRef]
  10. D. Yelin, I. Rizvi, W. White, J. Motz, T. Hasan, B. Bouma, and G. Tearney, “Three-dimensional miniature endoscopy,” Nature443, 765 (2006). [CrossRef] [PubMed]
  11. E. J. Seibel, C. M. Brown, J. A. Dominitz, and M. B. Kimmey, “Scanning single fiber endoscopy: a new platform technology for integrated laser imaging, diagnosis, and future therapies,” Gastrointest. Endosc. Clin. N. Am.18, 467–478 (2008). [CrossRef] [PubMed]
  12. D. Yelin, B. E. Bouma, S. H. Yun, and G. J. Tearney, “Double-clad fiber for endoscopy,” Opt. Lett.29, 2408–2410 (2004). [CrossRef] [PubMed]
  13. S. Lemire-Renaud, M. Rivard, M. Strupler, D. Morneau, F. Verpillat, X. Daxhelet, N. Godbout, and C. Boudoux, “Double-clad fiber coupler for endoscopy,” Opt. Express18, 9755–9764 (2010). [CrossRef] [PubMed]
  14. T. Wilson and A. R. Carlini, “Size of the detector in confocal imaging systems,” Opt. Lett.12, 227–229 (1987). [CrossRef] [PubMed]
  15. M. Gu, Principles of Three Dimensional Imaging in Confocal Microscopes (World Scientific, 1996). [CrossRef]
  16. A. Snyder and J. Love, Optical Waveguide Theory, (Chapman and Hall, 1983).
  17. T. Wilson, “Image formation in two-mode fiber-based confocal microscopes,” J. Opt. Soc. Am. A10, 1535–1543 (1993). [CrossRef]
  18. M. Gu, C. J. R. Sheppard, and X. Gan, “Image formation in a fiber-optical confocal scanning microscope,” J. Opt. Soc. Am. A8, 1755–1761 (1991). [CrossRef]
  19. J. Goodman, Speckle Phenomena in Optics: Theory and Applications (Roberts & Co., 2007).
  20. H. Bao, S. Y. Ryu, B. H. Lee, W. Tao, and M. Gu, “Nonlinear endomicroscopy using a double-clad fiber coupler,” Opt. Lett.35, 995–997 (2010). [CrossRef] [PubMed]
  21. G. Liu and Z. Chen, “Fiber-based combined optical coherence and multiphoton endomicroscopy,” J. Biomed. Opt.16, 036010 (2011). [CrossRef] [PubMed]
  22. Y. Wu, Y. Leng, J. Xi, and X. Li, “Scanning all-fiber-optic endomicroscopy system for 3d nonlinear optical imaging of biological tissues,” Opt. Express17, 7907–7915 (2009). [CrossRef] [PubMed]
  23. S. Y. Ryu, H. Y. Choi, J. Na, E. S. Choi, and B. H. Lee, “Combined system of optical coherence tomography and fluorescence spectroscopy based on double-cladding fiber,” Opt. Lett.33, 2347–2349 (2008). [CrossRef] [PubMed]
  24. L. Wang, H. Y. Choi, Y. Jung, B. H. Lee, and K.-T. Kim, “Optical probe based on double-clad optical fiber for fluorescence spectroscopy,” Opt. Express15, 17681–17689 (2007). [CrossRef] [PubMed]
  25. S.-Y. Ryu, H.-Y. Choi, M.-J. Ju, J.-H. Na, W.-J. Choi, and B.-H. Lee, “The development of double clad fiber and double clad fiber coupler for fiber based biomedical imaging systems,” J. Opt. Soc. Korea13, 310–315 (2009). [CrossRef]
  26. L. Fu and M. Gu, “Double-clad photonic crystal fiber coupler for compact nonlinear optical microscopy imaging,” Opt. Lett.31, 1471–1473 (2006). [CrossRef] [PubMed]
  27. J. Bures, Guided Optics: Optical Fibers and All-Fiber Components (Wiley-VCH, 2008).
  28. G. J. Tearney, R. H. Webb, and B. E. Bouma, “Spectrally encoded confocal microscopy,” Opt. Lett.23, 1152–1154 (1998). [CrossRef]
  29. D. Yelin, W. M. White, J. T. Motz, S. H. Yun, B. E. Bouma, and G. J. Tearney, “Spectral-domain spectrally-encoded endoscopy,” Opt. Express15, 2432–2444 (2007). [CrossRef] [PubMed]
  30. S. Lacroix, N. Godbout, and X. Daxhelet, Optical fiber components: design and applications (Research Signpost, India, 2006), chap. Optical fiber components: design and applications of fused biconical tapered components, Habib Hamam, ed.
  31. S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett.28, 1981–1983 (2003). [CrossRef] [PubMed]
  32. C. Boudoux, S. Yun, W. Oh, W. White, N. Iftimia, M. Shishkov, B. Bouma, and G. Tearnet, “Rapid wavelength-swept spectrally encoded confocal microscopy,” Opt. Express13(20), 8214–8221 (2005). [CrossRef] [PubMed]
  33. M. Strupler, E. D. Montigny, D. Morneau, and C. Boudoux, “Rapid spectrally encoded fluorescence imaging using a wavelength-swept source,” Opt. Lett.35, 1737–1739 (2010). [CrossRef] [PubMed]
  34. C. Boudoux, S. C. Leuin, W. Y. Oh, M. J. Suter, A. E. Desjardins, B. J. Vakoc, B. E. Bouma, C. J. Hartnick, and G. J. Tearney, “Optical microscopy of the pediatric vocal fold,” Arch. Otolaryngol. Head Neck Surg.135, 53–64 (2009). [CrossRef] [PubMed]

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