OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 3 — Mar. 1, 2011
  • pp: 421–430

Novel focused OCT-LIF endoscope

R. Andrew Wall, Garret T. Bonnema, and Jennifer K. Barton  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 3, pp. 421-430 (2011)
http://dx.doi.org/10.1364/BOE.2.000421


View Full Text Article

Enhanced HTML    Acrobat PDF (889 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Combined optical coherence tomography (OCT) and laser-induced fluorescence (LIF) endoscopy has shown higher sensitivity and specificity for distinguishing normal tissue from adenoma when compared to either modality alone. Endoscope optical design is complicated by the large wavelength difference between the two systems. A new high-resolution endoscope 2 mm in diameter is presented that can create focused beams from the ultraviolet to near-infrared. A reflective design ball lens operates achromatically over a large wavelength range, and employs TIR at two faces and reflection at a third internal mirrored face. The 1:1 imaging system obtains theoretically diffraction-limited spots for both the OCT (1300 nm) and LIF (325 nm) channels.

© 2011 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2680) Medical optics and biotechnology : Gastrointestinal
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: September 14, 2010
Revised Manuscript: November 4, 2010
Manuscript Accepted: January 28, 2011
Published: January 31, 2011

Citation
R. Andrew Wall, Garret T. Bonnema, and Jennifer K. Barton, "Novel focused OCT-LIF endoscope," Biomed. Opt. Express 2, 421-430 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-3-421


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. Cancer Facts & Figs, 2010 (American Cancer Society, Atlanta, Georgia, 2009). http://www.cancer.org/downloads/STT/Cancer_Facts_and_Figures_2010.pdf .
  2. A. Das, M. V. Sivak, A. Chak, R. C. Wong, V. Westphal, A. M. Rollins, J. Willis, G. Isenberg, and J. A. Izatt, “High-resolution endoscopic imaging of the GI tract: a comparative study of optical coherence tomography versus high-frequency catheter probe EUS,” Gastrointest. Endosc. 54(2), 219–224 (2001). [CrossRef] [PubMed]
  3. B. E. Bouma, and G. J. Tearney, eds., Handbook of Optical Coherence Tomography (Marcel Dekker, New York, 2002).
  4. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  5. M. V. Sivak, K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, “High-resolution endoscopic imaging of the GI tract using optical coherence tomography,” Gastrointest. Endosc. 51(4), 474–479 (2000). [CrossRef] [PubMed]
  6. E. Zagaynova, N. Gladkova, N. Shakhova, G. Gelikonov, and V. Gelikonov, “Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology,” J Biophotonics 1(2), 114–128 (2008). [CrossRef] [PubMed]
  7. D. C. Adler, C. Zhou, T. H. Tsai, J. Schmitt, Q. Huang, H. Mashimo, and J. G. Fujimoto, “Three-dimensional endomicroscopy of the human colon using optical coherence tomography,” Opt. Express 17(2), 784–796 (2009). [CrossRef] [PubMed]
  8. A. R. Tumlinson, B. Povazay, L. P. Hariri, J. McNally, A. Unterhuber, B. Hermann, H. Sattmann, W. Drexler, and J. K. Barton, “In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope,” J. Biomed. Opt. 11(6), 064003 (2006). [CrossRef] [PubMed]
  9. L. P. Hariri, A. R. Tumlinson, N. H. Wade, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract,” Comp. Med. 57(2), 175–185 (2007). [PubMed]
  10. L. P. Hariri, Z. Qiu, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, N. A. Ignatenko, B. Povazay, B. Hermann, H. Sattmann, J. McNally, A. Unterhuber, W. Drexler, and J. K. Barton, “Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography,” Cancer Biol. Ther. 6(11), 1753–1762 (2007). [CrossRef] [PubMed]
  11. R. Richards-Kortum, R. P. Rava, R. E. Petras, M. Fitzmaurice, M. Sivak, and M. S. Feld, “Spectroscopic diagnosis of colonic dysplasia,” Photochem. Photobiol. 53(6), 777–786 (1991). [PubMed]
  12. A. Lucas, M. J. Radosavljevic, E. Lu, and E. J. Gaffney, “Characterization of human coronary artery atherosclerotic plaque fluorescence emission,” Can. J. Cardiol. 6(6), 219–228 (1990). [PubMed]
  13. J. J. Baraga, R. P. Rava, P. Taroni, C. Kittrell, M. Fitzmaurice, and M. S. Feld, “Laser induced fluorescence spectroscopy of normal and atherosclerotic human aorta using 306-310 nm excitation,” Lasers Surg. Med. 10(3), 245–261 (1990). [CrossRef] [PubMed]
  14. N. Ramanujam, “Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,” Neoplasia 2(1/2), 89–117 (2000). [CrossRef] [PubMed]
  15. A. L. Alexander, C. M. Connor Davenport, and A. F. Gmitro, “Comparison of illumination wavelengths for detection of atherosclerosis by optical fluorescence spectroscopy,” Opt. Eng. 33(1), 167 (1994). [CrossRef]
  16. R. L. Prosst and J. Gahlen, “Fluorescence diagnosis of colorectal neoplasms: a review of clinical applications,” Int. J. Colorectal Dis. 17(1), 1–10 (2002). [CrossRef] [PubMed]
  17. M. Hassan and B. A. Klaunberg, “Biomedical applications of fluorescence imaging in vivo,” Comp. Med. 54(6), 635–644 (2004). [PubMed]
  18. S. Fu, C. T. Chia, C. L. Tang, C. H. Diong, and C. Seow, “Changes in in-vivo autofluorescence spectra at different periods in rat colorectal tumor progression,” Proc. SPIE 4432, 118–123 (2001). [CrossRef]
  19. E. M. Kanter, R. M. Walker, S. L. Marion, M. Brewer, P. B. Hoyer, and J. K. Barton, “Dual modality imaging of a novel rat model of ovarian carcinogenesis,” J. Biomed. Opt. 11(4), 041123 (2006). [CrossRef] [PubMed]
  20. L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, U. Utzinger, E. W. Gerner, and J. K. Barton, “Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model,” Lasers Surg. Med. 38(4), 305–313 (2006). [CrossRef] [PubMed]
  21. Y. Luo, P. J. Gelsinger-Austin, J. M. Watson, G. Barbastathis, J. K. Barton, and R. K. Kostuk, “Laser-induced fluorescence imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system,” Opt. Lett. 33(18), 2098–2100 (2008). [CrossRef] [PubMed]
  22. L. P. Hariri, E. R. Liebmann, S. L. Marion, P. B. Hoyer, J. R. Davis, M. A. Brewer, and J. K. Barton, “Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis,” Cancer Biol. Ther. 10(5), 438–447 (2010). [CrossRef] [PubMed]
  23. R. V. Kuranov, V. V. Sapozhnikova, H. M. Shakhova, V. M. Gelikonov, E. V. Zagainova, and S. A. Petrova, “Combined application of optical methods to increase the information content of optical coherent tomography in diagnostics of neoplastic processes,” Quantum Electron. 32(11), 993–998 (2002). [CrossRef]
  24. J. K. Barton, A. Tumlinson, and U. Utzinger, “Combined endoscopic optical coherence tomography and laser induced fluorescence,” in Optical Coherence Tomography: Technology and Applications, W. Drexler and J. Fujimoto, eds. (Springer, 2008).
  25. S. Y. Ryu, H. Y. Choi, J. Na, E. S. Choi, and B. H. Lee, “Combined system of optical coherence tomography and fluorescence spectroscopy based on double-cladding fiber,” Opt. Lett. 33(20), 2347–2349 (2008). [CrossRef] [PubMed]
  26. J. B. McNally, N. D. Kirkpatrick, L. P. Hariri, A. R. Tumlinson, D. G. Besselsen, E. W. Gerner, U. Utzinger, and J. K. Barton, “Task-based imaging of colon cancer in the Apc(Min/+) mouse model,” Appl. Opt. 45(13), 3049–3062 (2006). [CrossRef] [PubMed]
  27. A. R. Tumlinson, L. P. Hariri, U. Utzinger, and J. K. Barton, “Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement,” Appl. Opt. 43(1), 113–121 (2004). [CrossRef] [PubMed]
  28. J. A. Izatt, M. D. Kulkarni, S. Yazdanfar, J. K. Barton, and A. J. Welch, “In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography,” Opt. Lett. 22(18), 1439–1441 (1997). [CrossRef] [PubMed]
  29. T. J. Pfefer, L. S. Matchette, and R. Drezek, “Influence of illumination-collection geometry on fluorescence spectroscopy in multilayer tissue,” Med. Biol. Eng. Comput. 42(5), 669–673 (2004). [CrossRef] [PubMed]
  30. T. J. Pfefer, L. S. Matchette, A. M. Ross, and M. N. Ediger, “Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design,” Opt. Lett. 28(2), 120–122 (2003). [CrossRef] [PubMed]
  31. T. J. Pfefer, K. T. Schomacker, M. N. Ediger, and N. S. Nishioka, “Multiple-fiber probe design for fluorescence spectroscopy in tissue,” Appl. Opt. 41(22), 4712–4721 (2002). [CrossRef] [PubMed]
  32. R. R. Shannon, “Aberrations,” in The Art and Science of Optical Design (Cambridge University Press, 2006).
  33. J. Sasian, “Optical Design with Mirrors,” presented at Optical Design and Testing Short Course Program, Kyoto, Japan, 15–16 November 1997.
  34. Eksma Optics, “Metallic Coatings,” http://www.eksmaoptics.com/en/p/metallic-coatings-35
  35. E. Hecht, “Propagation of light,” in Optics, 4th ed. (Addison Wesley, 2001).
  36. S. W. Smith, “Special imaging techniques,” in The Scientist and Engineer’s Guide to Digital Signal Processing (California Technical Publishing, 1997), pp. 423–430.
  37. A. Douplik, D. Chen, M. K. Akens, S. Zanati, M. Cirocco, N. Bassett, N. E. Marcon, J. Fengler, and B. C. Wilson, “Assessment of photobleaching during endoscopic autofluorescence imaging of the lower GI tract,” Lasers Surg. Med. 42(3), 224–231 (2010). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited