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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 4 — Apr. 1, 2011
  • pp: 781–793

Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope

Johnny Tam, Pavan Tiruveedhula, and Austin Roorda  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 4, pp. 781-793 (2011)
http://dx.doi.org/10.1364/BOE.2.000781


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Abstract

Adaptive Optics Scanning Laser Ophthalmoscopy was used to noninvasively acquire videos of single-file flow through live human retinal parafoveal capillaries. Videos were analyzed offline to investigate capillary flow dynamics. Certain capillaries accounted for a clear majority of leukocyte traffic (Leukocyte-Preferred-Paths, LPPs), while other capillaries primarily featured plasma gap flow (Plasma-Gap-Capillaries, PGCs). LPPs may serve as a protective mechanism to prevent inactivated leukocytes from entering exchange capillaries, and PGCs may serve as relief valves to minimize flow disruption due to the presence of a leukocyte in a neighboring LPP.

© 2011 OSA

OCIS Codes
(110.2960) Imaging systems : Image analysis
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices
(110.1080) Imaging systems : Active or adaptive optics

ToC Category:
Cardiovascular Applications

History
Original Manuscript: January 6, 2011
Revised Manuscript: February 16, 2011
Manuscript Accepted: February 17, 2011
Published: March 2, 2011

Virtual Issues
Cellular Imaging of the Retina (2011) Biomedical Optics Express
March 11, 2011 Spotlight on Optics

Citation
Johnny Tam, Pavan Tiruveedhula, and Austin Roorda, "Characterization of single-file flow through human retinal parafoveal capillaries using an adaptive optics scanning laser ophthalmoscope," Biomed. Opt. Express 2, 781-793 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-4-781


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