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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1159–1168

Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension

Tilman Schmoll, Amardeep S. G. Singh, Cedric Blatter, Sabine Schriefl, Christian Ahlers, Ursula Schmidt-Erfurth, and Rainer A. Leitgeb  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 5, pp. 1159-1168 (2011)
http://dx.doi.org/10.1364/BOE.2.001159


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Abstract

Using a spectral domain OCT system, equipped with a broadband Ti:sapphire laser, we imaged the human retina with 5 µm x 1.3 µm transverse and axial resolution at acquisition rate of 100 kHz. Such imaging speed significantly reduces motion artifacts. Combined with the ultra-high resolution, this allows observing microscopic retinal details with high axial definition without the help of adaptive optics. In this work we apply our system to image the parafoveal capillary network. We demonstrate how already on the intensity level the parafoveal capillaries can be segmented by a simple structural high pass filtering algorithm. This data is then used to quantitatively characterize the capillary network of healthy and diseased eyes. We propose to use the fractal dimension as index for capillary integrity of pathologic disorders.

© 2011 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Ophthalmology Applications

History
Original Manuscript: January 4, 2011
Revised Manuscript: March 18, 2011
Manuscript Accepted: March 22, 2011
Published: April 12, 2011

Virtual Issues
In vivo Microcirculation Imaging (2011) Biomedical Optics Express

Citation
Tilman Schmoll, Amardeep S. G. Singh, Cedric Blatter, Sabine Schriefl, Christian Ahlers, Ursula Schmidt-Erfurth, and Rainer A. Leitgeb, "Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension," Biomed. Opt. Express 2, 1159-1168 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-5-1159


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