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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 5 — May. 1, 2011
  • pp: 1268–1274

In vivo volumetric imaging of chicken retina with ultrahigh-resolution spectral domain optical coherence tomography

Alireza Akhlagh Moayed, Sepideh Hariri, Eun Sun Song, Vivian Choh, and Kostadinka Bizheva  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 5, pp. 1268-1274 (2011)
http://dx.doi.org/10.1364/BOE.2.001268


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Abstract

The chicken retina is an established animal model for myopia and light-associated growth studies. It has a unique morphology: it is afoveate and avascular; oxygen and nutrition to the inner retina is delivered by a vascular tissue (pecten) that protrudes into the vitreous. Here we present, to the best of our knowledge, the first in vivo, volumetric high-resolution images of the chicken retina. Images were acquired with an ultrahigh-resolution optical coherence tomography (UHROCT) system with 3.5 ┬Ám axial resolution in the retina, at the rate of 47,000 A-scans/s. Spatial variations in the thickness of the nerve fiber and ganglion cell layers were mapped by segmenting and measuring the layer thickness with a semi-automatic segmentation algorithm. Volumetric visualization of the morphology and morphometric analysis of the chicken retina could aid significantly studies with chicken retinal models of ophthalmic diseases.

© 2011 OSA

OCIS Codes
(100.2960) Image processing : Image analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: March 3, 2011
Revised Manuscript: April 2, 2011
Manuscript Accepted: April 15, 2011
Published: April 19, 2011

Virtual Issues
Cellular Imaging of the Retina (2011) Biomedical Optics Express

Citation
Alireza Akhlagh Moayed, Sepideh Hariri, Eun Sun Song, Vivian Choh, and Kostadinka Bizheva, "In vivo volumetric imaging of chicken retina with ultrahigh-resolution spectral domain optical coherence tomography," Biomed. Opt. Express 2, 1268-1274 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-5-1268


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