OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 8 — Aug. 1, 2011
  • pp: 2348–2353

Integrated diffuse optical tomography and photoacoustic tomography: phantom validations

Xiaoqi Li, Lei Xi, Ruixin Jiang, Lei Yao, and Huabei Jiang  »View Author Affiliations

Biomedical Optics Express, Vol. 2, Issue 8, pp. 2348-2353 (2011)

View Full Text Article

Enhanced HTML    Acrobat PDF (1305 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We designed, fabricated and tested a novel imaging system that fuses diffuse optical tomography (DOT) and photoacoustic tomography (PAT) in a single platform. This platform takes advantages of both DOT and PAT, and can potentially provide dual-modality two dimensional functional and cellular images of the breast quantitatively. Here we describe this integrated platform along with initial tissue phantom validations.

© 2011 OSA

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.0110) Medical optics and biotechnology : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Multimodal Imaging

Original Manuscript: June 20, 2011
Revised Manuscript: July 19, 2011
Manuscript Accepted: July 19, 2011
Published: July 21, 2011

Xiaoqi Li, Lei Xi, Ruixin Jiang, Lei Yao, and Huabei Jiang, "Integrated diffuse optical tomography and photoacoustic tomography: phantom validations," Biomed. Opt. Express 2, 2348-2353 (2011)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009). [CrossRef] [PubMed]
  2. M. Pramanik, G. Ku, C. H. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008). [CrossRef] [PubMed]
  3. G. Ku, B. D. Fornage, X. Jin, M. Xu, K. K. Hunt, and L. V. Wang, “Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging,” Technol. Cancer Res. Treat. 4(5), 559–566 (2005). [PubMed]
  4. D. Piras, W. Xia, W. Steenbergen, T. G. Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010). [CrossRef]
  5. S. Manohar, S. E. Vaartjes, J. C. G. van Hespen, J. M. Klaase, F. M. van den Engh, W. Steenbergen, and T. G. van Leeuwen, “Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics,” Opt. Express 15(19), 12277–12285 (2007). [CrossRef] [PubMed]
  6. S. Manohar, A. Kharine, J. C. G. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “Photoacoustic mammography laboratory prototype: imaging of breast tissue phantoms,” J. Biomed. Opt. 9(6), 1172–1181 (2004). [CrossRef] [PubMed]
  7. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” Med. Phys. 37(11), 6096–6100 (2010). [CrossRef] [PubMed]
  8. L. Yao, Y. Sun, and H. Jiang, “Quantitative photoacoustic tomography based on the radiative transfer equation,” Opt. Lett. 34(12), 1765–1767 (2009). [CrossRef] [PubMed]
  9. Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett. 88(23), 231101 (2006). [CrossRef]
  10. B. T. Cox, J. G. Laufer, and P. C. Beard, “The challenges for quantitative photoacoustic imaging,” Proc. SPIE 7177, 717–713 (2009).
  11. C. Li and H. Jiang, “Imaging of particle size and concentration in heterogeneous turbid media with multispectral diffuse optical tomography,” Opt. Express 12(25), 6313–6318 (2004). [CrossRef] [PubMed]
  12. H. Jiang, N. V. Iftimia, Y. Xu, J. A. Eggert, L. L. Fajardo, and K. L. Klove, “Near-infrared optical imaging of the breast with model-based reconstruction,” Acad. Radiol. 9(2), 186–194 (2002). [CrossRef] [PubMed]
  13. C. Li, H. Zhao, B. Anderson, and H. Jiang, “Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system,” Med. Phys. 33(3), 627–636 (2006). [CrossRef] [PubMed]
  14. H. Jiang, K. D. Paulsen, U. L. Osterberg, and M. S. Patterson, “Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms,” Phys. Med. Biol. 43(3), 675–693 (1998). [CrossRef] [PubMed]
  15. N. Iftimia and H. Jiang, “Quantitative optical image reconstruction of turbid media by use of direct-current measurements,” Appl. Opt. 39(28), 5256–5261 (2000). [CrossRef] [PubMed]
  16. L. Yin, Q. Wang, Q. Zhang, and H. Jiang, “Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements,” Opt. Lett. 32(17), 2556–2558 (2007). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited