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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 9 — Sep. 1, 2011
  • pp: 2532–2539

Imaging with second-harmonic radiation probes in living tissue

Rachel Grange, Thomas Lanvin, Chia-Lung Hsieh, Ye Pu, and Demetri Psaltis  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 9, pp. 2532-2539 (2011)
http://dx.doi.org/10.1364/BOE.2.002532


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Abstract

We demonstrate that second-harmonic radiation imaging probes are efficient biomarkers for imaging in living tissue. We show that 100 nm and 300 nm BaTiO3 nanoparticles used as contrast markers could be detected through 50 μm and 120 μm of mouse tail tissue in vitro or in vivo. Experimental results and Monte-Carlo simulations are in good agreement.

© 2011 OSA

OCIS Codes
(160.4330) Materials : Nonlinear optical materials
(180.5810) Microscopy : Scanning microscopy
(290.7050) Scattering : Turbid media
(110.0113) Imaging systems : Imaging through turbid media
(160.4236) Materials : Nanomaterials

ToC Category:
Molecular Imaging and Probe Development

History
Original Manuscript: June 24, 2011
Revised Manuscript: July 29, 2011
Manuscript Accepted: July 29, 2011
Published: August 2, 2011

Citation
Rachel Grange, Thomas Lanvin, Chia-Lung Hsieh, Ye Pu, and Demetri Psaltis, "Imaging with second-harmonic radiation probes in living tissue," Biomed. Opt. Express 2, 2532-2539 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2532


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