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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 2, Iss. 9 — Sep. 1, 2011
  • pp: 2632–2648

Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information

Teresa Correia, Juan Aguirre, Alejandro Sisniega, Judit Chamorro-Servent, Juan Abascal, Juan J. Vaquero, Manuel Desco, Ville Kolehmainen, and Simon Arridge  »View Author Affiliations


Biomedical Optics Express, Vol. 2, Issue 9, pp. 2632-2648 (2011)
http://dx.doi.org/10.1364/BOE.2.002632


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Abstract

Fluorescence diffuse optical tomography (fDOT) is an imaging modality that provides images of the fluorochrome distribution within the object of study. The image reconstruction problem is ill-posed and highly underdetermined and, therefore, regularisation techniques need to be used. In this paper we use a nonlinear anisotropic diffusion regularisation term that incorporates anatomical prior information. We introduce a split operator method that reduces the nonlinear inverse problem to two simpler problems, allowing fast and efficient solution of the fDOT problem. We tested our method using simulated, phantom and ex-vivo mouse data, and found that it provides reconstructions with better spatial localisation and size of fluorochrome inclusions than using the standard Tikhonov penalty term.

© 2011 OSA

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Image Reconstruction and Inverse Problems

History
Original Manuscript: July 7, 2011
Revised Manuscript: August 14, 2011
Manuscript Accepted: August 15, 2011
Published: August 19, 2011

Citation
Teresa Correia, Juan Aguirre, Alejandro Sisniega, Judit Chamorro-Servent, Juan Abascal, Juan J. Vaquero, Manuel Desco, Ville Kolehmainen, and Simon Arridge, "Split operator method for fluorescence diffuse optical tomography using anisotropic diffusion regularisation with prior anatomical information," Biomed. Opt. Express 2, 2632-2648 (2011)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-2-9-2632


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