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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 1 — Jan. 1, 2012
  • pp: 125–136

Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood

I. Y. Petrov, Y. Petrov, D. S. Prough, D. J. Deyo, I. Cicenaite, and R. O. Esenaliev  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 1, pp. 125-136 (2012)

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There is strong clinical evidence that controlling cerebral venous oxygenation (oxyhemoglobin saturation) is critically important for patients with severe traumatic brain injury as well as for patients undergoing cardiac surgery. However, the only available method for cerebral venous blood oxygenation monitoring is invasive and requires catheterization of the internal jugular vein. We designed and built a novel optoacoustic monitor of cerebral venous oxygenation as measured in the superior sagittal sinus (SSS), the large midline cerebral vein. To the best of our knowledge, optical monitoring of cerebral venous blood oxygenation through overlying extracerebral blood is reported for the first time in this paper. The system was capable of detecting SSS signals in vivo at 700, 800, and 1064 nm through the thick (5–6 mm) sheep skull containing the circulating blood. The high (submillimeter) in-depth resolution of the system provided identification of the SSS peaks in the optoacoustic signals. The SSS peak amplitude closely followed the actual SSS blood oxygenation measured invasively using catheterization, blood sampling, and “gold standard” CO-Oximetry. Our data indicate the system may provide accurate measurement of the SSS blood oxygenation in patients with extracerebral blood over the SSS.

© 2011 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1460) Medical optics and biotechnology : Blood gas monitoring
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Cardiovascular Applications

Original Manuscript: November 14, 2011
Revised Manuscript: December 8, 2011
Manuscript Accepted: December 12, 2011
Published: December 14, 2011

I. Y. Petrov, Y. Petrov, D. S. Prough, D. J. Deyo, I. Cicenaite, and R. O. Esenaliev, "Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood," Biomed. Opt. Express 3, 125-136 (2012)

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