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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 10 — Oct. 1, 2012
  • pp: 2658–2668

Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher

Nicola Bellini, Francesca Bragheri, Ilaria Cristiani, Jochen Guck, Roberto Osellame, and Graeme Whyte  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 10, pp. 2658-2668 (2012)

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The combination of high power laser beams with microfluidic delivery of cells is at the heart of high-throughput, single-cell analysis and disease diagnosis with an optical stretcher. So far, the challenges arising from this combination have been addressed by externally aligning optical fibres with microfluidic glass capillaries, which has a limited potential for integration into lab-on-a-chip environments. Here we demonstrate the successful production and use of a monolithic glass chip for optical stretching of white blood cells, featuring microfluidic channels and optical waveguides directly written into bulk glass by femtosecond laser pulses. The performance of this novel chip is compared to the standard capillary configuration. The robustness, durability and potential for intricate flow patterns provided by this monolithic optical stretcher chip suggest its use for future diagnostic and biotechnological applications.

© 2012 OSA

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.4520) Medical optics and biotechnology : Optical confinement and manipulation
(350.3390) Other areas of optics : Laser materials processing

ToC Category:
Optical Traps, Manipulation, and Tracking

Original Manuscript: July 5, 2012
Revised Manuscript: August 31, 2012
Manuscript Accepted: September 3, 2012
Published: September 24, 2012

Nicola Bellini, Francesca Bragheri, Ilaria Cristiani, Jochen Guck, Roberto Osellame, and Graeme Whyte, "Validation and perspectives of a femtosecond laser fabricated monolithic optical stretcher," Biomed. Opt. Express 3, 2658-2668 (2012)

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