OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 12 — Dec. 1, 2012
  • pp: 3138–3152

Improved measurement of vibration amplitude in dynamic optical coherence elastography

Brendan F. Kennedy, Maciej Wojtkowski, Maciej Szkulmowski, Kelsey M. Kennedy, Karol Karnowski, and David D. Sampson  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 12, pp. 3138-3152 (2012)
http://dx.doi.org/10.1364/BOE.3.003138


View Full Text Article

Enhanced HTML    Acrobat PDF (4060 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Abstract: Optical coherence elastography employs optical coherence tomography (OCT) to measure the displacement of tissues under load and, thus, maps the resulting strain into an image, known as an elastogram. We present a new improved method to measure vibration amplitude in dynamic optical coherence elastography. The tissue vibration amplitude caused by sinusoidal loading is measured from the spread of the Doppler spectrum, which is extracted using joint spectral and time domain signal processing. At low OCT signal-to-noise ratio (SNR), the method provides more accurate vibration amplitude measurements than the currently used phase-sensitive method. For measurements performed on a mirror at OCT SNR = 5 dB, our method introduces <3% error, compared to >20% using the phase-sensitive method. We present elastograms of a tissue-mimicking phantom and excised porcine tissue that demonstrate improvements, including a 50% increase in the depth range of reliable vibration amplitude measurement.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(290.5820) Scattering : Scattering measurements
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: August 31, 2012
Revised Manuscript: November 5, 2012
Manuscript Accepted: November 5, 2012
Published: November 7, 2012

Citation
Brendan F. Kennedy, Maciej Wojtkowski, Maciej Szkulmowski, Kelsey M. Kennedy, Karol Karnowski, and David D. Sampson, "Improved measurement of vibration amplitude in dynamic optical coherence elastography," Biomed. Opt. Express 3, 3138-3152 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-12-3138


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. J. M. Schmitt, “OCT elastography: imaging microscopic deformation and strain of tissue,” Opt. Express3(6), 199–211 (1998). [CrossRef] [PubMed]
  2. J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: a quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging13(2), 111–134 (1991). [CrossRef] [PubMed]
  3. R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science269(5232), 1854–1857 (1995). [CrossRef] [PubMed]
  4. W. Drexler and J. G. Fujimoto, Optical Coherence Tomography: Technology and Applications (Springer-Verlag, Berlin, 2008).
  5. B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express3(8), 1865–1879 (2012). [CrossRef] [PubMed]
  6. R. C. Chan, A. H. Chau, W. C. Karl, S. Nadkarni, A. S. Khalil, N. Iftimia, M. Shishkov, G. J. Tearney, M. R. Kaazempur-Mofrad, and B. E. Bouma, “OCT-based arterial elastography: robust estimation exploiting tissue biomechanics,” Opt. Express12(19), 4558–4572 (2004). [CrossRef] [PubMed]
  7. J. Rogowska, N. A. Patel, J. G. Fujimoto, and M. E. Brezinski, “Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues,” Heart90(5), 556–562 (2004). [CrossRef] [PubMed]
  8. B. F. Kennedy, T. R. Hillman, A. Curatolo, and D. D. Sampson, “Speckle reduction in optical coherence tomography by strain compounding,” Opt. Lett.35(14), 2445–2447 (2010). [CrossRef] [PubMed]
  9. B. F. Kennedy, A. Curatolo, T. R. Hillman, C. M. Saunders, and D. D. Sampson, “Speckle reduction in optical coherence tomography images using tissue viscoelasticity,” J. Biomed. Opt.16(2), 020506 (2011). [CrossRef] [PubMed]
  10. T. R. Hillman, A. Curatolo, B. F. Kennedy, and D. D. Sampson, “Detection of multiple scattering in optical coherence tomography by speckle correlation of angle-dependent B-scans,” Opt. Lett.35(12), 1998–2000 (2010). [CrossRef] [PubMed]
  11. R. K. Wang, Z. H. Ma, and S. J. Kirkpatrick, “Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue,” Appl. Phys. Lett.89(14), 144103 (2006). [CrossRef]
  12. B. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm,” Opt. Express13(11), 3931–3944 (2005). [CrossRef] [PubMed]
  13. A. Szkulmowska, M. Szkulmowski, A. Kowalczyk, and M. Wojtkowski, “Phase-resolved Doppler optical coherence tomography—limitations and improvements,” Opt. Lett.33(13), 1425–1427 (2008). [CrossRef] [PubMed]
  14. K. M. Kennedy, B. F. Kennedy, R. A. McLaughlin, and D. D. Sampson, “Needle optical coherence elastography for tissue boundary detection,” Opt. Lett.37(12), 2310–2312 (2012). [CrossRef] [PubMed]
  15. X. Liang, A. L. Oldenburg, V. Crecea, E. J. Chaney, and S. A. Boppart, “Optical micro-scale mapping of dynamic biomechanical tissue properties,” Opt. Express16(15), 11052–11065 (2008). [CrossRef] [PubMed]
  16. S. G. Adie, X. Liang, B. F. Kennedy, R. John, D. D. Sampson, and S. A. Boppart, “Spectroscopic optical coherence elastography,” Opt. Express18(25), 25519–25534 (2010). [CrossRef] [PubMed]
  17. X. Liang, S. G. Adie, R. John, and S. A. Boppart, “Dynamic spectral-domain optical coherence elastography for tissue characterization,” Opt. Express18(13), 14183–14190 (2010). [CrossRef] [PubMed]
  18. B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express19(7), 6623–6634 (2011). [CrossRef] [PubMed]
  19. A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, “Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues,” Opt. Express16(15), 11525–11539 (2008). [PubMed]
  20. D. C. Adler, S. W. Huang, R. Huber, and J. G. Fujimoto, “Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography,” Opt. Express16(7), 4376–4393 (2008). [CrossRef] [PubMed]
  21. R. K. Wang and A. L. Nuttall, “Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of Corti at a subnanometer scale: a preliminary study,” J. Biomed. Opt.15(5), 056005 (2010). [CrossRef] [PubMed]
  22. B. F. Kennedy, T. R. Hillman, R. A. McLaughlin, B. C. Quirk, and D. D. Sampson, “In vivo dynamic optical coherence elastography using a ring actuator,” Opt. Express17(24), 21762–21772 (2009). [CrossRef] [PubMed]
  23. C. Li, Z. Huang, and R. K. Wang, “Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry,” Opt. Express19(11), 10153–10163 (2011). [CrossRef] [PubMed]
  24. C. Li, G. Guan, X. Cheng, Z. Huang, and R. K. Wang, “Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography,” Opt. Lett.37(4), 722–724 (2012). [CrossRef] [PubMed]
  25. R. K. Manapuram, S. R. Aglyamov, F. M. Monediado, M. Mashiatulla, J. Li, S. Y. Emelianov, and K. V. Larin, “In vivo estimation of elastic wave parameters using phase-stabilized swept source optical coherence elastography,” J. Biomed. Opt.17(10), 100501 (2012). [CrossRef]
  26. X. Liang, M. Orescanin, K. S. Toohey, M. F. Insana, and S. A. Boppart, “Acoustomotive optical coherence elastography for measuring material mechanical properties,” Opt. Lett.34(19), 2894–2896 (2009). [CrossRef] [PubMed]
  27. M. Razani, A. Mariampillai, C. Sun, T. W. H. Luk, V. X. D. Yang, and M. C. Kolios, “Feasibility of optical coherence elastography measurements of shear wave propagation in homogeneous tissue equivalent phantoms,” Biomed. Opt. Express3(5), 972–980 (2012). [CrossRef] [PubMed]
  28. D. C. Ghiglia and M. D. Pritt, Two-Dimensional Phase Unwrapping: Theory, Algorithms, and Software (Wiley, New York, 1998).
  29. M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, A. Kowalczyk, and M. Wojtkowski, “Flow velocity estimation using joint Spectral and Time domain Optical Coherence Tomography,” Opt. Express16(9), 6008–6025 (2008). [CrossRef] [PubMed]
  30. M. Szkulmowski, I. Grulkowski, D. Szlag, A. Szkulmowska, A. Kowalczyk, and M. Wojtkowski, “Flow velocity estimation by complex ambiguity free joint Spectral and Time domain Optical Coherence Tomography,” Opt. Express17(16), 14281–14297 (2009). [CrossRef] [PubMed]
  31. S. G. Adie, B. F. Kennedy, J. J. Armstrong, S. A. Alexandrov, and D. D. Sampson, “Audio frequency in vivo optical coherence elastography,” Phys. Med. Biol.54(10), 3129–3139 (2009). [CrossRef] [PubMed]
  32. D. D. Sampson and T. R. Hillman, “Optical coherence tomography,” in Lasers And Current Optical Techniques In Biology, G. Palumbo and R. Pratesi, eds. (ESP Comprehensive Series in Photosciences, Cambridge, UK, 2004), pp. 481–571.
  33. O. Sasaki and H. Okazaki, “Sinusoidal phase modulating interferometry for surface profile measurement,” Appl. Opt.25(18), 3137–3140 (1986). [CrossRef] [PubMed]
  34. S. R. Huang, R. M. Lerner, and K. J. Parker, “On estimating the amplitude of harmonic vibration from the Doppler spectrum of reflected signals,” J. Acoust. Soc. Am.88(6), 2702–2712 (1990). [CrossRef]
  35. A. Bruce Carlson, P. B. Crilly, and J. C. Rutledge, Communications Systems (McGraw-Hill, New York, 2002).
  36. S. Haykin, Communication Systems (Wiley, New York, 2001).
  37. K. Kristoffersen, “Time-domain estimation of the center frequency and spread of Doppler spectra in diagnostic ultrasound,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control35(6), 685–700 (1988). [CrossRef] [PubMed]
  38. G. Lamouche, B. F. Kennedy, K. M. Kennedy, C. E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express3(6), 1381–1398 (2012). [CrossRef] [PubMed]
  39. R. N. Bracewell, The Fourier Transform and Its Applications (McGraw-Hill, New York, 1999).
  40. M. Wojtkowski, A. Kowalczyk, R. Leitgeb, and A. F. Fercher, “Full range complex spectral optical coherence tomography technique in eye imaging,” Opt. Lett.27(16), 1415–1417 (2002). [CrossRef] [PubMed]
  41. E. W. Chang, J. B. Kobler, and S. H. Yun, “Triggered optical coherence tomography for capturing rapid periodic motion,” Sci. Rep.1, 48 (2011). [CrossRef] [PubMed]
  42. G. Liu, M. Rubinstein, A. Saidi, W. Qi, A. Foulad, B. Wong, and Z. Chen, “Imaging vibrating vocal folds with a high speed 1050 nm swept source OCT and ODT,” Opt. Express19(12), 11880–11889 (2011). [CrossRef] [PubMed]
  43. F. Chen, D. Zha, A. Fridberger, J. Zheng, N. Choudhury, S. L. Jacques, R. K. Wang, X. Shi, and A. L. Nuttall, “A differentially amplified motion in the ear for near-threshold sound detection,” Nat. Neurosci.14(6), 770–774 (2011). [CrossRef] [PubMed]
  44. E. W. Chang, J. B. Kobler, and S. H. Yun, “Subnanometer optical coherence tomographic vibrography,” Opt. Lett.37(17), 3678–3680 (2012). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited