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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 12 — Dec. 1, 2012
  • pp: 3240–3249

Iterative algorithm for multiple illumination photoacoustic tomography (MIPAT) using ultrasound channel data

Peng Shao, Tyler Harrison, and Roger J. Zemp  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 12, pp. 3240-3249 (2012)

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Photoacoustic tomography is a promising imaging modality offering high ultrasonic resolution with intrinsic optical contrast. However, quantification in photoacoustic imaging is challenging. We present an algorithm for quantitative photoacoustic estimation of optical absorption and diffusion coefficients based on minimizing an error function between measured photoacoustic channel data and a calculated forward model with a multiple-illumination pattern. Unlike many other algorithms, the proposed method does not require the erroneous assumption of ideal tomographic reconstruction of initial pressures and to our knowledge is the first demonstration of the efficacy of multiple-illumination photoacoustic tomography requiring only transducer channel data. Simulations show promise for numerically robust optical property estimation as illustrated by well-conditioned Hessian singular values in 2D examples.

© 2012 OSA

OCIS Codes
(100.0100) Image processing : Image processing
(100.3010) Image processing : Image reconstruction techniques

ToC Category:
Image Reconstruction and Inverse Problems

Original Manuscript: July 23, 2012
Revised Manuscript: September 25, 2012
Manuscript Accepted: September 25, 2012
Published: November 13, 2012

Peng Shao, Tyler Harrison, and Roger J. Zemp, "Iterative algorithm for multiple illumination photoacoustic tomography (MIPAT) using ultrasound channel data," Biomed. Opt. Express 3, 3240-3249 (2012)

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