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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 3 — Mar. 1, 2012
  • pp: 590–604

Quantitative comparison of optimized nanorods, nanoshells and hollow nanospheres for photothermal therapy

Sameh Kessentini and Dominique Barchiesi  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 3, pp. 590-604 (2012)

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The purpose of this study is to get more efficient gold nanoparticles, for necrosis of cancer cells, in photothermal therapy. Therefore a numerical maximization of the absorption efficiency of a set of nanoparticles (nanorod, nanoshell and hollow nanosphere) is proposed, assuming that all the absorbed light is converted to heat. Two therapeutic cases (shallow and deep cancer) are considered. The numerical tools used in this study are the full Mie theory, the discrete dipole approximation and the particle swarm optimization. The optimization leads to an improved efficiency of the nanoparticles compared with previous studies. For the shallow cancer therapy, the hollow nanosphere seems to be more efficient than the other nanoparticles, whereas the hollow nanosphere and nanorod, offer comparable absorption efficiencies, for deep cancer therapy. Finally, a study of tolerance for the size parameters to guarantee an absorption efficiency threshold is included.

© 2012 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1020) Medical optics and biotechnology : Ablation of tissue
(170.5180) Medical optics and biotechnology : Photodynamic therapy
(350.5340) Other areas of optics : Photothermal effects

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: November 29, 2011
Revised Manuscript: January 25, 2012
Manuscript Accepted: January 27, 2012
Published: February 22, 2012

Sameh Kessentini and Dominique Barchiesi, "Quantitative comparison of optimized nanorods, nanoshells and hollow nanospheres for photothermal therapy," Biomed. Opt. Express 3, 590-604 (2012)

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