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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 5 — May. 1, 2012
  • pp: 826–839

Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography

Bahar Davoudi, Andras Lindenmaier, Beau A. Standish, Ghassan Allo, Kostadinka Bizheva, and Alex Vitkin  »View Author Affiliations


Biomedical Optics Express, Vol. 3, Issue 5, pp. 826-839 (2012)
http://dx.doi.org/10.1364/BOE.3.000826


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Abstract

A spectral domain optical coherence tomography (SD-OCT) system and an oral imaging probe have been developed to visualize the microstructural morphology and microvasculature in the human oral cavity. Structural OCT images of ex vivo pig oral tissues with the histology of the same sites were acquired and compared for correlations. Structural in vivo OCT images of healthy human tissue as well as a pathologic site (ulcer) were obtained and analyzed based on the results of the ex vivo pig study, drawing on the similarity between human and swine oral tissues. In vivo Doppler and speckle variance OCT images of the oral cavity in human volunteers were also acquired, to demonstrate the feasibility of microvascular imaging of healthy and pathologic (scar) oral tissue.

© 2012 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: January 30, 2012
Revised Manuscript: March 20, 2012
Manuscript Accepted: March 23, 2012
Published: April 2, 2012

Citation
Bahar Davoudi, Andras Lindenmaier, Beau A. Standish, Ghassan Allo, Kostadinka Bizheva, and Alex Vitkin, "Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography," Biomed. Opt. Express 3, 826-839 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-5-826


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