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In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopyKert Edward, Suimin Qiu, Vicente Resto, Susan McCammon, and Gracie Vargas »View Author Affiliations
Kert Edward,1,*
Suimin Qiu,2,5
Vicente Resto,3,5
Susan McCammon,3,5
and Gracie Vargas1,4,5
1Center for Biomedical Engineering, The University of Texas Medical Branch, Galveston, TX 77555, USA 2Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA 3Department of Otolaryngology, The University of Texas Medical Branch, Galveston, TX 77555, USA 4Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, TX 77555, USA 5Center for Cancers of the Head and Neck, The University of Texas Medical Branch, Galveston, TX 77555, USA *Corresponding author: k3edward@utmb.edu |
Biomedical Optics Express, Vol. 3, Issue 7, pp. 1579-1593 (2012)
http://dx.doi.org/10.1364/BOE.3.001579
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Abstract
Optical spectroscopy has proven to be a powerful technique for studying neoplastic transformation in epithelial tissue. Since specific intra-layer precancerous changes originate in the stratified layers of the oral mucosa, layer-resolved analysis will likely improve both our understanding of the mechanism of premalignant transformation, and clinical diagnostic outcomes. However, the native fluorescence signal in linear spectroscopy typically originates from a multi-layered focal volume. In this study, nonlinear spectroscopy was exploited for in vivo layer-resolved discrimination between normal and dysplastic tissue for the first time. Our results revealed numerous intra-layer specific differences.
© 2012 OSA
OCIS Codes
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5810) Medical optics and biotechnology : Scanning microscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(190.4180) Nonlinear optics : Multiphoton processes
ToC Category:
Optics in Cancer Research
History
Original Manuscript: January 31, 2012
Revised Manuscript: May 15, 2012
Manuscript Accepted: May 15, 2012
Published: June 12, 2012
Citation
Kert Edward, Suimin Qiu, Vicente Resto, Susan McCammon, and Gracie Vargas, "In vivo layer-resolved characterization of oral dysplasia via nonlinear optical micro-spectroscopy," Biomed. Opt. Express 3, 1579-1593 (2012)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-3-7-1579
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- S. Zhuo, J. Chen, X. Jiang, S. Xie, R. Chen, N. Cao, Q. Zou, and S. Xiong, “The layered-resolved microstructure and spectroscopy of mouse oral mucosa using multiphoton microscopy,” Phys. Med. Biol.52(16), 4967–4980 (2007). [CrossRef] [PubMed]
- J. Chen, S. Zhuo, R. Chen, X. Jiang, S. Xie, and Q. Zou, “Depth-resolved spectral imaging of rabbit esophageal tissue based on two-photon excited fluorescence and second-harmonic generation,” New J. Phys.9(7), 212 (2007). [CrossRef]
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- C. Y. Wang, H. K. Chiang, C. T. Chen, C. P. Chiang, Y. S. Kuo, and S. N. Chow, “Diagnosis of oral cancer by light-induced autofluorescence spectroscopy using double excitation wavelengths,” Oral Oncol.35(2), 144–150 (1999). [CrossRef] [PubMed]
- C. Y. Wang, H. K. Chiang, C. T. Chen, C. P. Chiang, Y. S. Kuo, and S. N. Chow, “Diagnosis of oral cancer by light-induced autofluorescence spectroscopy using double excitation wavelengths,” Oral Oncol.35(2), 144–150 (1999). [CrossRef] [PubMed]
- L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010). [CrossRef] [PubMed]
- L. B. Lovat, K. Johnson, G. D. Mackenzie, B. R. Clark, M. R. Novelli, S. Davies, M. O’Donovan, C. Selvasekar, S. M. Thorpe, D. Pickard, R. C. Fitzgerald, T. Fearn, I. J. Bigio, and S. G. Bown, “Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett’s oesophagus,” Gut55(8), 1078–1083 (2006). [CrossRef] [PubMed]
- A. Gillenwater, R. Jacob, R. Ganeshappa, B. Kemp, A. K. El-Naggar, J. L. Palmer, G. Clayman, M. F. Mitchell, and R. Richards-Kortum, “Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence,” Arch. Otolaryngol. Head Neck Surg.124(11), 1251–1258 (1998). [PubMed]
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- D. C. G. De Veld, M. J. Witjes, H. J. Sterenborg, and J. L. Roodenburg, “The status of in vivo autofluorescence spectroscopy and imaging for oral oncology,” Oral Oncol.41(2), 117–131 (2005). [CrossRef] [PubMed]
- M. C. Skala, G. M. Palmer, C. Zhu, Q. Liu, K. M. Vrotsos, C. L. Marshek-Stone, A. Gendron-Fitzpatrick, and N. Ramanujam, “Investigation of fiber-optic probe designs for optical spectroscopic diagnosis of epithelial pre-cancers,” Lasers Surg. Med.34(1), 25–38 (2004). [CrossRef] [PubMed]
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- A. Zoumi, A. Yeh, and B. J. Tromberg, “Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescence,” Proc. Natl. Acad. Sci. U.S.A.99(17), 11014–11019 (2002). [CrossRef] [PubMed]
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- B. W. Neville and T. A. Day, “Oral cancer and precancerous lesions,” CA Cancer J. Clin.52(4), 195–215 (2002). [CrossRef] [PubMed]
- G. Zuccaro, N. Gladkova, J. Vargo, F. Feldchtein, E. Zagaynova, D. Conwell, G. Falk, J. Goldblum, J. Dumot, J. Ponsky, G. Gelikonov, B. Davros, E. Donchenko, and J. Richter, “Optical coherence tomography of the esophagus and proximal stomach in health and disease,” Am. J. Gastroenterol.96(9), 2633–2639 (2001). [CrossRef] [PubMed]
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- L. Coghlan, U. Utzinger, R. Drezek, D. Heintzelmann, A. Zuluaga, C. Brookner, R. Richards-Kortum, I. Gimenez-Conti, and M. Follen, “Optimal fluorescence excitation wavelengths for detection of squamous intra-epithelial neoplasia: results from an animal model,” Opt. Express7(12), 436–446 (2000). [CrossRef] [PubMed]
- C. Y. Wang, H. K. Chiang, C. T. Chen, C. P. Chiang, Y. S. Kuo, and S. N. Chow, “Diagnosis of oral cancer by light-induced autofluorescence spectroscopy using double excitation wavelengths,” Oral Oncol.35(2), 144–150 (1999). [CrossRef] [PubMed]
- A. Gillenwater, R. Jacob, R. Ganeshappa, B. Kemp, A. K. El-Naggar, J. L. Palmer, G. Clayman, M. F. Mitchell, and R. Richards-Kortum, “Noninvasive diagnosis of oral neoplasia based on fluorescence spectroscopy and native tissue autofluorescence,” Arch. Otolaryngol. Head Neck Surg.124(11), 1251–1258 (1998). [PubMed]
- R. Richards-Kortum and E. Sevick-Muraca, “Quantitative optical spectroscopy for tissue diagnosis,” Annu. Rev. Phys. Chem.47(1), 555–606 (1996). [CrossRef] [PubMed]
- H. Lumerman, P. Freedman, and S. Kerpel, “Oral epithelial dysplasia and the development of invasive squamous cell carcinoma,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.79(3), 321–329 (1995). [CrossRef] [PubMed]
- I. B. Gimenez-Conti and T. J. Slaga, “The hamster cheek pouch carcinogenesis model,” J. Cell. Biochem. Suppl.53(S17F), 83–90 (1993). [CrossRef] [PubMed]
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990). [CrossRef] [PubMed]
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