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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 3, Iss. 8 — Aug. 1, 2012
  • pp: 1947–1954

Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter  »View Author Affiliations

Biomedical Optics Express, Vol. 3, Issue 8, pp. 1947-1954 (2012)

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Transbronchial needle aspiration (TBNA) is a procedure routinely performed to diagnose peripheral pulmonary lesions. However, TBNA is associated with a low diagnostic yield due to inappropriate needle placement. We have developed a flexible transbronchial optical frequency domain imaging (TB-OFDI) catheter that functions as a “smart needle” to confirm the needle placement within the target lesion prior to biopsy. The TB-OFDI smart needle consists of a flexible and removable OFDI catheter (430 µm dia.) that operates within a standard 21-gauge TBNA needle. The OFDI imaging core is based on an angle polished ball lens design with a working distance of 160 µm from the catheter sheath and a spot size of 25 µm. To demonstrate the potential of the TB-OFDI smart needle for transbronchial imaging, an inflated excised swine lung was imaged through a standard bronchoscope. Cross-sectional and longitudinal OFDI results reveal the detailed network of alveoli in the lung parenchyma suggesting that the TB-OFDI smart needle may be a useful tool for guiding biopsy acquisition to increase the diagnostic yield.

© 2012 OSA

OCIS Codes
(060.2350) Fiber optics and optical communications : Fiber optics imaging
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: May 30, 2012
Revised Manuscript: July 26, 2012
Manuscript Accepted: July 27, 2012
Published: July 27, 2012

K. M. Tan, M. Shishkov, A. Chee, M. B. Applegate, B. E. Bouma, and M. J. Suter, "Flexible transbronchial optical frequency domain imaging smart needle for biopsy guidance," Biomed. Opt. Express 3, 1947-1954 (2012)

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  1. America Cancer Society, “Cancer facts and figures 2010” (ACS, 2010).
  2. S. Altekruse, C. Kosary, M. Krapcho, N. Neyman, R. Aminou, W. Waldron, J. Ruhl, N. Howlader, Z. Tatalovich, and H. Cho, “SEER cancer statistics review” (National Cancer Institute, Bethesda, MD, 2010).
  3. A. B. Mariotto, K. R. Yabroff, Y. Shao, E. J. Feuer, and M. L. Brown, “Projections of the cost of cancer care in the United States: 2010–2020,” J. Natl. Cancer Inst.103(2), 117–128 (2011). [CrossRef] [PubMed]
  4. W. A. Baaklini, M. A. Reinoso, A. B. Gorin, A. Sharafkaneh, and P. Manian, “Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules,” Chest117(4), 1049–1054 (2000). [CrossRef] [PubMed]
  5. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  6. S. Yun, G. Tearney, J. de Boer, N. Iftimia, and B. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express11(22), 2953–2963 (2003). [CrossRef] [PubMed]
  7. M. Tsuboi, A. Hayashi, N. Ikeda, H. Honda, Y. Kato, S. Ichinose, and H. Kato, “Optical coherence tomography in the diagnosis of bronchial lesions,” Lung Cancer49(3), 387–394 (2005). [CrossRef] [PubMed]
  8. S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res.14(7), 2006–2011 (2008). [CrossRef] [PubMed]
  9. R. G. Michel, G. T. Kinasewitz, K. M. Fung, and J. I. Keddissi, “Optical coherence tomography as an adjunct to flexible bronchoscopy in the diagnosis of lung cancer: a pilot study,” Chest138(4), 984–988 (2010). [CrossRef] [PubMed]
  10. H. O. Coxson, B. Quiney, D. D. Sin, L. Xing, A. M. McWilliams, J. R. Mayo, and S. Lam, “Airway wall thickness assessed using computed tomography and optical coherence tomography,” Am. J. Respir. Crit. Care Med.177(11), 1201–1206 (2008). [CrossRef] [PubMed]
  11. J. J. Armstrong, M. S. Leigh, D. D. Sampson, J. H. Walsh, D. R. Hillman, and P. R. Eastwood, “Quantitative upper airway imaging with anatomic optical coherence tomography,” Am. J. Respir. Crit. Care Med.173(2), 226–233 (2006). [CrossRef] [PubMed]
  12. X. D. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000). [CrossRef] [PubMed]
  13. V. X. D. Yang, Y. X. Mao, N. Munce, B. Standish, W. Kucharczyk, N. E. Marcon, B. C. Wilson, and I. A. Vitkin, “Interstitial Doppler optical coherence tomography,” Opt. Lett.30(14), 1791–1793 (2005). [CrossRef] [PubMed]
  14. A. M. Zysk, D. L. Marks, D. Y. Liu, and S. A. Boppart, “Needle-based reflection refractometry of scattering samples using coherence-gated detection,” Opt. Express15(8), 4787–4794 (2007). [CrossRef] [PubMed]
  15. D. Lorenser, X. Yang, R. W. Kirk, B. C. Quirk, R. A. McLaughlin, and D. D. Sampson, “Ultrathin side-viewing needle probe for optical coherence tomography,” Opt. Lett.36(19), 3894–3896 (2011). [CrossRef] [PubMed]
  16. Y Wu, J. Xi, L. Huo, J. Padvorac, E. J. Shin, S. A. Giday, A. A. Lennon, M. I. F. Canto, J. H. Hwang, and X. Li, “Robust high-resolution fine OCT needle for side-viewing interstitial tissue imaging,” IEEE J. Sel. Top. Quantum Electron.16(4), 863–869 (2010). [CrossRef]
  17. B. C. Quirk, R. A. McLaughlin, A. Curatolo, R. W. Kirk, P. B. Noble, and D. D. Sampson, “In situ imaging of lung alveoli with an optical coherence tomography needle probe,” J. Biomed. Opt.16(3), 036009 (2011). [CrossRef] [PubMed]
  18. W. C. Kuo, J. Kim, N. D. Shemonski, E. J. Chaney, D. R. Spillman, and S. A. Boppart, “Real-time three-dimensional optical coherence tomography image-guided core-needle biopsy system,” Biomed. Opt. Express3(6), 1149–1161 (2012). [CrossRef] [PubMed]
  19. M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc.68(4), 745–753 (2008). [CrossRef] [PubMed]
  20. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express11(22), 2953–2963 (2003). [CrossRef] [PubMed]
  21. J. H. Han, X. Liu, C. G. Song, and J. U. Kang, “Common path optical coherence tomography with fibre bundle probe,” Electron. Lett.45(22), 1110–1112 (2009). [CrossRef] [PubMed]
  22. S. Han, M. V. Sarunic, J. Wu, M. Humayun, and C. H. Yang, “Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection,” J. Biomed. Opt.13(2), 020505 (2008). [CrossRef] [PubMed]
  23. C. P. Liang, J. Wierwille, T. Moreira, G. Schwartzbauer, M. S. Jafri, C. M. Tang, and Y. Chen, “A forward-imaging needle-type OCT probe for image guided stereotactic procedures,” Opt. Express19(27), 26283–26294 (2011). [CrossRef] [PubMed]
  24. E. J. Min, J. Na, S. Y. Ryu, and B. H. Lee, “Single-body lensed-fiber scanning probe actuated by magnetic force for optical imaging,” Opt. Lett.34(12), 1897–1899 (2009). [CrossRef] [PubMed]

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