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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 1 — Jan. 1, 2013
  • pp: 105–121

Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy

David R. Busch, Regine Choe, Mark A. Rosen, Wensheng Guo, Turgut Durduran, Michael D. Feldman, Carolyn Mies, Brian J. Czerniecki, Julia Tchou, Angela DeMichele, Mitchell D. Schnall, and Arjun G. Yodh  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 1, pp. 105-121 (2013)

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We introduce and demonstrate use of a novel, diffuse optical tomography (DOT) based breast cancer signature for monitoring progression of neoadjuvant chemotherapy. This signature, called probability of malignancy, is obtained by statistical image analysis of total hemoglobin concentration, blood oxygen saturation, and scattering coefficient distributions in the breast tomograms of a training-set population with biopsy-confirmed breast cancers. A pilot clinical investigation adapts this statistical image analysis approach for chemotherapy monitoring of three patients. Though preliminary, the study shows how to use the malignancy parameter for separating responders from partial-responders and demonstrates the potential utility of the methodology compared to traditional DOT quantification schemes.

© 2012 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3830) Medical optics and biotechnology : Mammography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optics in Cancer Research

Original Manuscript: September 11, 2012
Revised Manuscript: November 27, 2012
Manuscript Accepted: November 28, 2012
Published: December 14, 2012

David R. Busch, Regine Choe, Mark A. Rosen, Wensheng Guo, Turgut Durduran, Michael D. Feldman, Carolyn Mies, Brian J. Czerniecki, Julia Tchou, Angela DeMichele, Mitchell D. Schnall, and Arjun G. Yodh, "Optical malignancy parameters for monitoring progression of breast cancer neoadjuvant chemotherapy," Biomed. Opt. Express 4, 105-121 (2013)

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