OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 10 — Oct. 1, 2013
  • pp: 2166–2178

Comparative review of interferometric detection of plasmonic nanoparticles

Adam Wax, Amihai Meiri, Siddarth Arumugam, and Matthew T. Rinehart  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 10, pp. 2166-2178 (2013)

View Full Text Article

Enhanced HTML    Acrobat PDF (1949 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Noble metal nanoparticles exhibit enhanced scattering and absorption at specific wavelengths due to a localized surface plamson resonance. This unique property can be exploited to enable the use of plasmonic nanoparticles as contrast agents in optical imaging. A range of optical techniques have been developed to detect nanoparticles in order to implement imaging schemes. Here we review several different approaches for using optical interferometry to detect the presence and concentration of nanoparticles. The strengths and weaknesses of the various approaches are discussed and quantitative comparisons of the achievable signal to noise ratios are presented. The benefits of each approach are outlined as they relate to specific application goals.

© 2013 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.1650) Medical optics and biotechnology : Coherence imaging
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: June 17, 2013
Revised Manuscript: September 4, 2013
Manuscript Accepted: September 5, 2013
Published: September 16, 2013

Virtual Issues
Optical Molecular Probes, Imaging, and Drug Delivery (2013) Biomedical Optics Express

Adam Wax, Amihai Meiri, Siddarth Arumugam, and Matthew T. Rinehart, "Comparative review of interferometric detection of plasmonic nanoparticles," Biomed. Opt. Express 4, 2166-2178 (2013)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. K. Seekell, H. Price, S. Marinakos, A. Wax, “Optimization of immunolabeled plasmonic nanoparticles for cell surface receptor analysis,” Methods 56(2), 310–316 (2012). [CrossRef] [PubMed]
  2. M. Grzelczak, J. Pérez-Juste, P. Mulvaney, L. M. Liz-Marzán, “Shape control in gold nanoparticle synthesis,” Chem. Soc. Rev. 37(9), 1783–1791 (2008). [CrossRef] [PubMed]
  3. P. Alexandridis, “Gold nanoparticle synthesis, morphology control, and stabilization facilitated by functional polymers,” Chem. Eng. Technol. 34(1), 15–28 (2011). [CrossRef]
  4. P. P. Joshi, S. J. Yoon, W. G. Hardin, S. Emelianov, and K. V. Sokolov, “Conjugation of Antibodies to Gold Nanorods through Fc Portion: Synthesis and Molecular Specific Imaging,” Bioconj. Chem. (2013).
  5. K. S. Lee, M. A. El-Sayed, “Gold and silver nanoparticles in sensing and imaging: Sensitivity of plasmon response to size, shape, and metal composition,” J. Phys. Chem. B 110(39), 19220–19225 (2006). [CrossRef] [PubMed]
  6. A. Wax, K. Sokolov, “Molecular imaging and darkfield microspectroscopy of live cells using gold plasmonic nanoparticles,” Laser Photon. Rev. 3(1-2), 146–158 (2009). [CrossRef]
  7. K. Seekell, M. J. Crow, S. Marinakos, J. Ostrander, A. Chilkoti, A. Wax, “Hyperspectral molecular imaging of multiple receptors using immunolabeled plasmonic nanoparticles,” J. Biomed. Opt. 16(11), 116003 (2011). [CrossRef] [PubMed]
  8. I. H. El-Sayed, X. H. Huang, M. A. El-Sayed, “Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer,” Nano Lett. 5(5), 829–834 (2005). [CrossRef] [PubMed]
  9. X. H. Huang, I. H. El-Sayed, W. Qian, M. A. El-Sayed, “Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods,” J. Am. Chem. Soc. 128(6), 2115–2120 (2006). [CrossRef] [PubMed]
  10. K. Sokolov, M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan, R. Richards-Kortum, “Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles,” Cancer Res. 63(9), 1999–2004 (2003). [PubMed]
  11. S. W. Tsai, Y. Y. Chen, J. W. Liaw, “Compound cellular imaging of laser scanning confocal microscopy by using gold nanoparticles and dyes,” Sensors (Basel Switzerland) 8(4), 2306–2316 (2008). [CrossRef]
  12. T. Collier, A. Lacy, R. Richards-Kortum, A. Malpica, M. Follen, “Near real-time confocal microscopy of amelanotic tissue: detection of dysplasia in ex vivo cervical tissue,” Acad. Radiol. 9(5), 504–512 (2002). [CrossRef] [PubMed]
  13. N. J. Durr, T. Larson, D. K. Smith, B. A. Korgel, K. Sokolov, A. Ben-Yakar, “Two-photon luminescence imaging of cancer cells using molecularly targeted gold nanorods,” Nano Lett. 7(4), 941–945 (2007). [CrossRef] [PubMed]
  14. J. R. Cook, W. Frey, S. Emelianov, “Quantitative Photoacoustic Imaging of Nanoparticles in Cells and Tissues,” ACS Nano 7(2), 1272–1280 (2013). [CrossRef] [PubMed]
  15. M. C. Skala, M. J. Crow, A. Wax, J. A. Izatt, “Photothermal Optical Coherence Tomography of Epidermal Growth Factor Receptor in Live Cells Using Immunotargeted Gold Nanospheres,” Nano Lett. 8(10), 3461–3467 (2008). [CrossRef] [PubMed]
  16. J.A. Izatt, M.D. Kulkarni, K. Kobayashi, J.K. Barton, A.J. Welch, “Optical coherence tomography for biodiagnostics,” Opt. Photon. News 8, 41-47, 65 (1997).
  17. I. Yamaguchi, T. Zhang, “Phase-shifting digital holography,” Opt. Lett. 22(16), 1268–1270 (1997). [CrossRef] [PubMed]
  18. C. Mann, L. Yu, C.-M. Lo, M. Kim, “High-resolution quantitative phase-contrast microscopy by digital holography,” Opt. Express 13(22), 8693–8698 (2005). [CrossRef] [PubMed]
  19. A. Curry, W. L. Hwang, A. Wax, “Epi-illumination through the microscope objective applied to darkfield imaging and microspectroscopy of nanoparticle interaction with cells in culture,” Opt. Express 14(14), 6535–6542 (2006). [CrossRef] [PubMed]
  20. A. Wax, M. G. Giacomelli, T. E. Matthews, M. T. Rinehart, F. E. Robles, Y. Zhu, “Optical Spectroscopy of Biological Cells,” Adv. Opt. Photon. 4(3), 322–378 (2012). [CrossRef]
  21. C. Loo, L. Hirsch, M. H. Lee, E. Chang, J. West, N. Halas, R. Drezek, “Gold nanoshell bioconjugates for molecular imaging in living cells,” Opt. Lett. 30(9), 1012–1014 (2005). [CrossRef] [PubMed]
  22. M. J. Crow, G. Grant, J. M. Provenzale, A. Wax, “Molecular Imaging and Quantitative Measurement of Epidermal Growth Factor Receptor Expression in Live Cancer Cells Using Immunolabeled Gold Nanoparticles,” AJR Am. J. Roentgenol. 192(4), 1021–1028 (2009). [CrossRef] [PubMed]
  23. J. Gao, X. Huang, H. Liu, F. Zan, J. Ren, “Colloidal Stability of Gold Nanoparticles Modified with Thiol Compounds: Bioconjugation and Application in Cancer Cell Imaging,” Langmuir 28(9), 4464–4471 (2012). [CrossRef] [PubMed]
  24. G. Rong, H. Wang, L. R. Skewis, B. M. Reinhard, “Resolving Sub-Diffraction Limit Encounters in Nanoparticle Tracking Using Live Cell Plasmon Coupling Microscopy,” Nano Lett. 8(10), 3386–3393 (2008). [CrossRef] [PubMed]
  25. M. J. Crow, K. Seekell, J. H. Ostrander, A. Wax, “Monitoring of Receptor Dimerization Using Plasmonic Coupling of Gold Nanoparticles,” ACS Nano 5(11), 8532–8540 (2011). [CrossRef] [PubMed]
  26. J. Aaron, K. Travis, N. Harrison, K. Sokolov, “Dynamic Imaging of Molecular Assemblies in Live Cells Based on Nanoparticle Plasmon Resonance Coupling,” Nano Lett. 9(10), 3612–3618 (2009). [CrossRef] [PubMed]
  27. D. Boyer, P. Tamarat, A. Maali, B. Lounis, M. Orrit, “Photothermal Imaging of Nanometer-Sized Metal Particles Among Scatterers,” Science 297(5584), 1160–1163 (2002). [CrossRef] [PubMed]
  28. L. Cognet, C. Tardin, D. Boyer, D. Choquet, P. Tamarat, B. Lounis, “Single metallic nanoparticle imaging for protein detection in cells,” Proc. Natl. Acad. Sci. U.S.A. 100(20), 11350–11355 (2003). [CrossRef] [PubMed]
  29. V. P. Zharov, D. O. Lapotko, “Photothermal imaging of nanoparticles and cells,” IEEE J. Sel. Top. Quantum Electron. 11(4), 733–751 (2005). [CrossRef]
  30. G. Popescu, Chapter 5 Quantitative Phase Imaging of Nanoscale Cell Structure and Dynamics, in Methods in Cell Biology, P.J. Bhanu, Editor. 2008, Academic Press. p. 87–115.
  31. G. Baffou, P. Bon, J. Savatier, J. Polleux, M. Zhu, M. Merlin, H. Rigneault, S. Monneret, “Thermal Imaging of Nanostructures by Quantitative Optical Phase Analysis,” ACS Nano 6(3), 2452–2458 (2012). [CrossRef] [PubMed]
  32. S. Berciaud, L. Cognet, G. A. Blab, B. Lounis, “Photothermal Heterodyne Imaging of Individual Nonfluorescent Nanoclusters and Nanocrystals,” Phys. Rev. Lett. 93(25), 257402 (2004). [CrossRef] [PubMed]
  33. A. Gaiduk, P. V. Ruijgrok, M. Yorulmaz, M. Orrit, “Detection limits in photothermal microscopy,” Chem. Sci. 1(3), 343–350 (2010). [CrossRef]
  34. C. Yang, “Molecular Contrast Optical Coherence Tomography: A Review,” Photochem. Photobiol. 81(2), 215–237 (2005). [CrossRef] [PubMed]
  35. B. E. Applegate, J. A. Izatt, “Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography,” Opt. Express 14(20), 9142–9155 (2006). [CrossRef] [PubMed]
  36. F. E. Robles, C. Wilson, G. Grant, A. Wax, “Molecular imaging true-colour spectroscopic optical coherence tomography,” Nat. Photonics 5(12), 744–747 (2011). [CrossRef] [PubMed]
  37. A. L. Oldenburg, M. N. Hansen, D. A. Zweifel, A. Wei, S. A. Boppart, “Plasmon-resonant gold nanorods as low backscattering albedo contrast agents for optical coherence tomography,” Opt. Express 14(15), 6724–6738 (2006). [CrossRef] [PubMed]
  38. A. L. Oldenburg, M. N. Hansen, T. S. Ralston, A. Wei, S. A. Boppart, “Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography,” J. Mater. Chem. 19(35), 6407–6411 (2009). [CrossRef] [PubMed]
  39. Y. L. Li, K. Seekell, H. Yuan, F. E. Robles, A. Wax, “Multispectral nanoparticle contrast agents for true-color spectroscopic optical coherence tomography,” Biomed. Opt. Express 3(8), 1914–1923 (2012). [CrossRef] [PubMed]
  40. F. Robles, R. N. Graf, A. Wax, “Dual window method for processing spectroscopic optical coherence tomography signals with simultaneously high spectral and temporal resolution,” Opt. Express 17(8), 6799–6812 (2009). [CrossRef] [PubMed]
  41. J. M. Tucker-Schwartz, T. A. Meyer, C. A. Patil, C. L. Duvall, M. C. Skala, “In vivo photothermal optical coherence tomography of gold nanorod contrast agents,” Biomed. Opt. Express 3(11), 2881–2895 (2012). [CrossRef] [PubMed]
  42. S. Kim, M. T. Rinehart, H. Park, Y. Zhu, A. Wax, “Phase-sensitive OCT imaging of multiple nanoparticle species using spectrally multiplexed single pulse photothermal excitation,” Biomed. Opt. Express 3(10), 2579–2586 (2012). [CrossRef] [PubMed]
  43. D. C. Adler, S.-W. Huang, R. Huber, J. G. Fujimoto, “Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography,” Opt. Express 16(7), 4376–4393 (2008). [CrossRef] [PubMed]
  44. C. Pache, N. L. Bocchio, A. Bouwens, M. Villiger, C. Berclaz, J. Goulley, M. I. Gibson, C. Santschi, T. Lasser, “Fast three-dimensional imaging of gold nanoparticles in living cells with photothermal optical lock-in Optical Coherence Microscopy,” Opt. Express 20(19), 21385–21399 (2012). [CrossRef] [PubMed]
  45. M. Atlan, M. Gross, P. Desbiolles, É. Absil, G. Tessier, M. Coppey-Moisan, “Heterodyne holographic microscopy of gold particles,” Opt. Lett. 33(5), 500–502 (2008). [CrossRef] [PubMed]
  46. K. J. Chalut, W. J. Brown, A. Wax, “Quantitative phase microscopy with asynchronous digital holography,” Opt. Express 15(6), 3047–3052 (2007). [CrossRef] [PubMed]
  47. E. Absil, G. Tessier, M. Gross, M. Atlan, N. Warnasooriya, S. Suck, M. Coppey-Moisan, D. Fournier, “Photothermal heterodyne holography of gold nanoparticles,” Opt. Express 18(2), 780–786 (2010). [CrossRef] [PubMed]
  48. N. Warnasooriya, F. Joud, P. Bun, G. Tessier, M. Coppey-Moisan, P. Desbiolles, M. Atlan, M. Abboud, M. Gross, “Imaging gold nanoparticles in living cell environments using heterodyne digital holographic microscopy,” Opt. Express 18(4), 3264–3273 (2010). [CrossRef] [PubMed]
  49. F. Verpillat, F. Joud, P. Desbiolles, M. Gross, “Dark-field digital holographic microscopy for 3D-tracking of gold nanoparticles,” Opt. Express 19(27), 26044–26055 (2011). [CrossRef] [PubMed]
  50. G. Popescu, Quantitative phase imaging of cells and tissues (McGraw-Hill New York 2011).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited