OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 10 — Oct. 1, 2013
  • pp: 2231–2246

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Rebecca Re, Davide Contini, Massimo Turola, Lorenzo Spinelli, Lucia Zucchelli, Matteo Caffini, Rinaldo Cubeddu, and Alessandro Torricelli  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 10, pp. 2231-2246 (2013)
http://dx.doi.org/10.1364/BOE.4.002231


View Full Text Article

Enhanced HTML    Acrobat PDF (2058 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment.

© 2013 OSA

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Clinical Instrumentation

History
Original Manuscript: July 26, 2013
Revised Manuscript: September 12, 2013
Manuscript Accepted: September 17, 2013
Published: September 24, 2013

Citation
Rebecca Re, Davide Contini, Massimo Turola, Lorenzo Spinelli, Lucia Zucchelli, Matteo Caffini, Rinaldo Cubeddu, and Alessandro Torricelli, "Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing," Biomed. Opt. Express 4, 2231-2246 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-10-2231


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. Ferrari and V. Quaresima, “A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application,” Neuroimage63(2), 921–935 (2012). [CrossRef] [PubMed]
  2. D. Contini, L. Zucchelli, L. Spinelli, M. Caffini, R. Re, A. Pifferi, R. Cubeddu, and A. Torricelli, “Review: Brain and muscle near infrared spectroscopy/imaging techniques,” J. Near Infrared Spectrosc.20(1), 15–27 (2012). [CrossRef]
  3. M. Wolf, M. Ferrari, and V. Quaresima, “Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications,” J. Biomed. Opt.12(6), 062104 (2007). [CrossRef] [PubMed]
  4. A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage (Available online 5 June 2013).
  5. J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol.46(3), 879–896 (2001). [CrossRef] [PubMed]
  6. J. Selb, D. K. Joseph, and D. A. Boas, “Time-gated optical system for depth-resolved functional brain imaging,” J. Biomed. Opt.11(4), 044008 (2006). [CrossRef] [PubMed]
  7. D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, and R. Cubeddu, “Novel method for depth-resolved brain functional imaging by time-domain NIRS,” Proc. SPIE6629, 662908, 662908-7 (2007). [CrossRef]
  8. A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Möller, R. Macdonald, A. Villringer, and H. Rinneberg, “Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons,” Appl. Opt.43(15), 3037–3047 (2004). [CrossRef] [PubMed]
  9. E. Kirilina, A. Jelzow, A. Heine, M. Niessing, H. Wabnitz, R. Brühl, B. Ittermann, A. M. Jacobs, and I. Tachtsidis, “The physiological origin of task-evoked systemic artefacts in functional near infrared spectroscopy,” Neuroimage61(1), 70–81 (2012). [CrossRef] [PubMed]
  10. H. Wabnitz, M. Möller, A. Liebert, A. Walter, R. Erdmann, O. Raitza, C. Drenckhahn, J. Dreier, H. Obrig, J. Steinbrink, and R. Macdonald, “A time-domain NIR brain imager applied in functional stimulation experiments,” Proc. SPIE5859, 58590H, 58590H-9 (2005). [CrossRef]
  11. H. Wabnitz, M. Moeller, A. Liebert, H. Obrig, J. Steinbrink, and R. Macdonald, “Time-resolved near-infrared spectroscopy and imaging of the adult human brain,” Adv. Exp. Med. Biol.662, 143–148 (2010). [CrossRef] [PubMed]
  12. A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage24(2), 426–435 (2005). [CrossRef] [PubMed]
  13. O. Steinkellner, C. Gruber, H. Wabnitz, A. Jelzow, J. Steinbrink, J. B. Fiebach, R. Macdonald, and H. Obrig, “Optical bedside monitoring of cerebral perfusion: technological and methodological advances applied in a study on acute ischemic stroke,” J. Biomed. Opt.15(6), 061708 (2010). [CrossRef] [PubMed]
  14. A. Liebert, H. Wabnitz, H. Obrig, R. Erdmann, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and J. Steinbrink, “Non-invasive detection of fluorescence from exogenous chromophores in the adult human brain,” Neuroimage31(2), 600–608 (2006). [CrossRef] [PubMed]
  15. A. Jelzow, H. Wabnitz, H. Obrig, R. Macdonald, and J. Steinbrink, “Separation of indocyanine green boluses in the human brain and scalp based on time-resolved in-vivo fluorescence measurements,” J. Biomed. Opt.17(5), 057003 (2012). [CrossRef] [PubMed]
  16. M. Kacprzak, A. Liebert, P. Sawosz, N. Zolek, and R. Maniewski, “Time-resolved optical imager for assessment of cerebral oxygenation,” J. Biomed. Opt.12(3), 034019 (2007). [CrossRef] [PubMed]
  17. M. Kacprzak, A. Liebert, W. Staszkiewicz, A. Gabrusiewicz, P. Sawosz, G. Madycki, and R. Maniewski, “Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery,” J. Biomed. Opt.17(1), 016002 (2012). [CrossRef] [PubMed]
  18. A. Liebert, P. Sawosz, D. Milej, M. Kacprzak, W. Weigl, M. Botwicz, J. Mączewska, K. Fronczewska, E. Mayzner-Zawadzka, L. Królicki, and R. Maniewski, “Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation,” J. Biomed. Opt.16(4), 046011 (2011). [CrossRef] [PubMed]
  19. J. C. Hebden, A. P. Gibson, T. Austin, R. M. Yusof, N. Everdell, D. T. Delpy, S. R. Arridge, J. H. Meek, and J. S. Wyatt, “Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography,” Phys. Med. Biol.49(7), 1117–1130 (2004). [CrossRef] [PubMed]
  20. T. Austin, A. P. Gibson, G. Branco, R. Md, Y. S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three-dimensional optical imaging of blood volume and oxygenation in the preterm brain,” Neuroimage31(4), 1426–1433 (2006).
  21. A. P. Gibson, T. Austin, N. L. Everdell, M. Schweiger, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate,” Neuroimage30(2), 521–528 (2006). [CrossRef] [PubMed]
  22. J. C. Hebden, S. Magazov, N. Everdell, and M. Varela, “A time-domain system for optical tomography of the newborn infant brain,” presented at nEUROPt Workshop, Non-invasive imaging of brain function and disease by pulsed near infrared light, Milan, 12–13 March 2012.
  23. J. C. Hebden, M. Varela, S. Magazov, N. Everdell, A. Gibson, J. Meek, and T. Austin, “Diffuse optical imaging of the newborn infant brain,” in Proceeding. of 9th IEEE International Symposium onBiomedical Imaging: from Nano to Macro, Barcelona, 2–5 May 2012. [CrossRef]
  24. J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, “Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation,” J. Biomed. Opt.10(1), 011013 (2005). [CrossRef] [PubMed]
  25. J. Selb and D. A. Boas, “A Second Generation Time-Domain Imaging System from MGH,” presented at nEUROPt Workshop, Non-invasive imaging of brain function and disease by pulsed near infrared light, Milan, 12–13 March 2012.
  26. J. Selb, B. B. Zimmermann, M. Martino, T. M. Ogden, and D. A. Boas, “Functional brain imaging with a supercontinuum time-domain NIRS system,” Proc. SPIE8578, 857807 (2013). [CrossRef]
  27. M. Diop, K. M. Tichauer, J. T. Elliott, M. Migueis, T.-Y. Lee, and K. St. Lawrence, “Time-resolved near-infrared technique for bedside monitoring of absolute cerebral blood flow,” Proc. SPIE7555, 75550Z (2007). [CrossRef]
  28. R. Re, D. Contini, M. Caffini, R. Cubeddu, L. Spinelli, and A. Torricelli, “A compact time-resolved system for near infrared spectroscopy based on wavelength space multiplexing,” Rev. Sci. Instrum.81(11), 113101 (2010). [CrossRef] [PubMed]
  29. D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, F. Paglia, and R. Cubeddu, “Multi-channel time-resolved system for functional near infrared spectroscopy,” Opt. Express14(12), 5418–5432 (2006). [CrossRef] [PubMed]
  30. A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. Sterenborg, J. M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt.44(11), 2104–2114 (2005). [CrossRef] [PubMed]
  31. H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, A. Pifferi, A. Torricelli, D. Contini, L. Zucchelli, L. Spinelli, R. Cubeddu, D. Milej, N. Zolek, M. Kacprzak, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni and G. Zaccanti, “Performance assessment of time-domain optical brain imagers: The neuropt protocol,” In Biomedical Optics, Technical Digest (Optical Society of America, 2012), paper BSu2A.4.
  32. International Elettrotechnical Commision, IEC 60825–1:2007, Edition 2. Safety of Laser Products - Part 1: Equipment Classification and Requirements (2007).
  33. H. Wabnitz, A. Pifferi, A. Torricelli, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, P. Sawosz, A. Liebert, R. Macdonald, and R. Cubeddu, “Assessment of basic instrumental performance of time-domain optical brain imagers,” Proc. SPIE7896, 789602, 789602-8 (2011). [CrossRef]
  34. D. Contini, F. Martelli, and G. Zaccanti, “Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory,” Appl. Opt.36(19), 4587–4599 (1997). [CrossRef] [PubMed]
  35. L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Accuracy of the nonlinear fitting procedure for time-resolved measurements on diffusive phantoms at NIR wavelengths,” Proc. SPIE7174, 717424, 717424-10 (2009). [CrossRef]
  36. A. Torricelli, L. Spinelli, J. Kaethner, J. Selbeck, A. Franceschini, P. Rozzi, and M. Zude, “Non-destructive optical assessment of photon path lengths in fruit during ripening: implications on design of continuous-wave sensors,” International Conference Of Agricultural Engineering, CIGR-AgEng2012,Valencia 8–12 July 2012, Papers Book, ISBN-10 84–615–9928–4.
  37. W. Louisell, Quantum Statistical Properties of Radiation (Wiley, New York, 1973).
  38. F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts,” J. Biomed. Opt.18(6), 066014 (2013). [CrossRef] [PubMed]
  39. L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express15(11), 6589–6604 (2007). [CrossRef] [PubMed]
  40. S. Del Bianco, F. Martelli, F. Cignini, G. Zaccanti, A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, and R. Cubeddu, “Liquid phantom for investigating light propagation through layered diffusive media,” Opt. Express12(10), 2102–2111 (2004). [CrossRef] [PubMed]
  41. J. C. Ye, S. Tak, K. E. Jang, J. Jung, and J. Jang, “NIRS-SPM: Statistical parametric mapping for near-infrared spectroscopy,” Neuroimage44(2), 428–447 (2009). [CrossRef] [PubMed]
  42. http://bisp.kaist.ac.kr/NIRS-SPM.html .

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited