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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 2 — Feb. 1, 2013
  • pp: 206–218

Optics InfoBase > Biomedical Optics Express > Volume 4 > Issue 2 > Page 206

Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs

Jonathan T. Elliott, Daniel Milej, Anna Gerega, Wojciech Weigl, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Adam Liebert, and Keith St. Lawrence  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 2, pp. 206-218 (2013)
http://dx.doi.org/10.1364/BOE.4.000206


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Abstract

Variance of time-of-flight distributions have been shown to be more sensitive to cerebral blood flow (CBF) during dynamic-contrast enhanced monitoring of neurotrauma patients than attenuation. What is unknown is the degree to which variance is affected by changes in extracerebral blood flow. Furthermore, the importance of acquiring the arterial input function (AIF) on quantitative analysis of the data is not yet clear. This animal study confirms that variance is both sensitive and specific to changes occurring in the brain when measurements are acquired on the surface of the scalp. Furthermore, when the variance data along with the measured AIF is analyzed using a nonparametric deconvolution method, the recovered change in CBF is in good agreement with CT perfusion values.

© 2013 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Optics of Tissue and Turbid Media

History
Original Manuscript: September 4, 2012
Revised Manuscript: October 22, 2012
Manuscript Accepted: November 20, 2012
Published: January 2, 2013

Citation
Jonathan T. Elliott, Daniel Milej, Anna Gerega, Wojciech Weigl, Mamadou Diop, Laura B. Morrison, Ting-Yim Lee, Adam Liebert, and Keith St. Lawrence, "Variance of time-of-flight distribution is sensitive to cerebral blood flow as demonstrated by ICG bolus-tracking measurements in adult pigs," Biomed. Opt. Express 4, 206-218 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-2-206


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