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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 2 — Feb. 1, 2013
  • pp: 230–240

In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography

Simon S. Gao, Patrick D. Raphael, Rosalie Wang, Jesung Park, Anping Xia, Brian E. Applegate, and John S. Oghalai  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 2, pp. 230-240 (2013)
http://dx.doi.org/10.1364/BOE.4.000230


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Abstract

Sound transduction within the auditory portion of the inner ear, the cochlea, is a complex nonlinear process. The study of cochlear mechanics in large rodents has provided important insights into cochlear function. However, technological and experimental limitations have restricted studies in mice due to their smaller cochlea. These challenges are important to overcome because of the wide variety of transgenic mouse strains with hearing loss mutations that are available for study. To accomplish this goal, we used spectral domain optical coherence tomography to visualize and measure sound-induced vibrations of intracochlear tissues. We present, to our knowledge, the first vibration measurements from the apex of an unopened mouse cochlea.

© 2013 OSA

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4940) Medical optics and biotechnology : Otolaryngology

ToC Category:
Otolaryngology

History
Original Manuscript: November 15, 2012
Revised Manuscript: January 11, 2013
Manuscript Accepted: January 14, 2013
Published: January 15, 2013

Citation
Simon S. Gao, Patrick D. Raphael, Rosalie Wang, Jesung Park, Anping Xia, Brian E. Applegate, and John S. Oghalai, "In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography," Biomed. Opt. Express 4, 230-240 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-2-230


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