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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 2 — Feb. 1, 2013
  • pp: 260–270

High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber

Ioannis N. Papadopoulos, Salma Farahi, Christophe Moser, and Demetri Psaltis  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 2, pp. 260-270 (2013)
http://dx.doi.org/10.1364/BOE.4.000260


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Abstract

We propose and experimentally demonstrate an ultra-thin rigid endoscope (450 μm diameter) based on a passive multimode optical fiber. We use digital phase conjugation to overcome the modal scrambling of the fiber to tightly focus and scan the laser light at its distal end. By exploiting the maximum number of modes available, sub-micron resolution, high quality fluorescence images of neuronal cells were acquired. The imaging system is evaluated in terms of fluorescence collection efficiency, resolution and field of view. The small diameter of the proposed endoscope, along with its high quality images offer an opportunity for minimally invasive medical endoscopic imaging and diagnosis based on cellular phenotype via direct tissue penetration.

© 2013 OSA

OCIS Codes
(070.5040) Fourier optics and signal processing : Phase conjugation
(110.2350) Imaging systems : Fiber optics imaging
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.7050) Medical optics and biotechnology : Turbid media
(090.1995) Holography : Digital holography

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: November 12, 2012
Revised Manuscript: January 8, 2013
Manuscript Accepted: January 8, 2013
Published: January 17, 2013

Virtual Issues
March 20, 2013 Spotlight on Optics

Citation
Ioannis N. Papadopoulos, Salma Farahi, Christophe Moser, and Demetri Psaltis, "High-resolution, lensless endoscope based on digital scanning through a multimode optical fiber," Biomed. Opt. Express 4, 260-270 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-2-260


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