OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 7 — Jul. 1, 2013
  • pp: 1119–1132

Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology

Tsung-Han Tsai, Benjamin Potsaid, Yuankai K. Tao, Vijaysekhar Jayaraman, James Jiang, Peter J. S. Heim, Martin F. Kraus, Chao Zhou, Joachim Hornegger, Hiroshi Mashimo, Alex E. Cable, and James G. Fujimoto  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 7, pp. 1119-1132 (2013)
http://dx.doi.org/10.1364/BOE.4.001119


View Full Text Article

Enhanced HTML    Acrobat PDF (8082 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 μm axial resolution, 8 μm lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated.

© 2013 OSA

OCIS Codes
(110.2350) Imaging systems : Fiber optics imaging
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.5800) Instrumentation, measurement, and metrology : Scanners
(140.3600) Lasers and laser optics : Lasers, tunable
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2680) Medical optics and biotechnology : Gastrointestinal
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: March 14, 2013
Revised Manuscript: June 4, 2013
Manuscript Accepted: June 6, 2013
Published: June 14, 2013

Citation
Tsung-Han Tsai, Benjamin Potsaid, Yuankai K. Tao, Vijaysekhar Jayaraman, James Jiang, Peter J. S. Heim, Martin F. Kraus, Chao Zhou, Joachim Hornegger, Hiroshi Mashimo, Alex E. Cable, and James G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4, 1119-1132 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-7-1119


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  2. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett.21(7), 543–545 (1996). [CrossRef] [PubMed]
  3. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997). [CrossRef] [PubMed]
  4. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I.-K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007). [CrossRef] [PubMed]
  5. D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007). [CrossRef]
  6. B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc.65(6), 898–905 (2007). [CrossRef] [PubMed]
  7. H. L. Fu, Y. X. Leng, M. J. Cobb, K. Hsu, J. H. Hwang, and X. D. Li, “Flexible miniature compound lens design for high-resolution optical coherence tomography balloon imaging catheter,” J. Biomed. Opt.13(6), 060502 (2008). [CrossRef] [PubMed]
  8. M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc.68(4), 745–753 (2008). [CrossRef] [PubMed]
  9. M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc.71(2), 346–353 (2010). [CrossRef] [PubMed]
  10. J. F. Xi, L. Huo, Y. C. Wu, M. J. Cobb, J. H. Hwang, and X. D. Li, “High-resolution OCT balloon imaging catheter with astigmatism correction,” Opt. Lett.34(13), 1943–1945 (2009). [CrossRef] [PubMed]
  11. W. Kang, H. Wang, Y. S. Pan, M. W. Jenkins, G. A. Isenberg, A. Chak, M. Atkinson, D. Agrawal, Z. L. Hu, and A. M. Rollins, “Endoscopically guided spectral-domain OCT with double-balloon catheters,” Opt. Express18(16), 17364–17372 (2010). [CrossRef] [PubMed]
  12. A. Sergeev, V. Gelikonov, G. Gelikonov, F. Feldchtein, R. Kuranov, N. Gladkova, N. Shakhova, L. Snopova, A. Shakhov, I. Kuznetzova, A. Denisenko, V. Pochinko, Y. Chumakov, and O. Streltzova, “In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa,” Opt. Express1(13), 432–440 (1997). [CrossRef] [PubMed]
  13. X. M. Liu, M. J. Cobb, Y. C. Chen, M. B. Kimmey, and X. D. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004). [CrossRef] [PubMed]
  14. A. D. Aguirre, J. Sawinski, S. W. Huang, C. Zhou, W. Denk, and J. G. Fujimoto, “High speed optical coherence microscopy with autofocus adjustment and a miniaturized endoscopic imaging probe,” Opt. Express18(5), 4222–4239 (2010). [CrossRef] [PubMed]
  15. T.-H. Tsai, B. Potsaid, M. F. Kraus, C. Zhou, Y. K. Tao, J. Hornegger, and J. G. Fujimoto, “Piezoelectric-transducer-based miniature catheter for ultrahigh-speed endoscopic optical coherence tomography,” Biomed. Opt. Express2(8), 2438–2448 (2011). [CrossRef] [PubMed]
  16. Y. T. Pan, H. K. Xie, and G. K. Fedder, “Endoscopic optical coherence tomography based on a microelectromechanical mirror,” Opt. Lett.26(24), 1966–1968 (2001). [CrossRef] [PubMed]
  17. W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, “Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror,” Appl. Phys. Lett.88(16), 163901 (2006). [CrossRef]
  18. K. H. Kim, B. H. Park, G. N. Maguluri, T. W. Lee, F. J. Rogomentich, M. G. Bancu, B. E. Bouma, J. F. de Boer, and J. J. Bernstein, “Two-axis magnetically-driven MEMS scanning catheter for endoscopic high-speed optical coherence tomography,” Opt. Express15(26), 18130–18140 (2007). [CrossRef] [PubMed]
  19. J. J. Sun, S. G. Guo, L. Wu, L. Liu, S. W. Choe, B. S. Sorg, and H. K. Xie, “3D in vivo optical coherence tomography based on a low-voltage, large-scan-range 2D MEMS mirror,” Opt. Express18(12), 12065–12075 (2010). [CrossRef] [PubMed]
  20. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, “In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe,” Opt. Lett.29(11), 1236–1238 (2004). [CrossRef] [PubMed]
  21. P. R. Herz, Y. Chen, A. D. Aguirre, K. Schneider, P. Hsiung, J. G. Fujimoto, K. Madden, J. Schmitt, J. Goodnow, and C. Petersen, “Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography,” Opt. Lett.29(19), 2261–2263 (2004). [CrossRef] [PubMed]
  22. S.-W. Lee, A. E. Heidari, D. Yoon, D. Mukai, T. Ramalingam, S. Mahon, J. Yin, J. Jing, G. Liu, Z. Chen, and M. Brenner, “Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography,” Biomed. Opt. Express2(2), 243–254 (2011). [CrossRef] [PubMed]
  23. S. Liang, A. Saidi, J. Jing, G. Liu, J. Li, J. Zhang, C. Sun, J. Narula, and Z. Chen, “Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner,” J. Biomed. Opt.17(7), 070501 (2012). [CrossRef] [PubMed]
  24. J. Li, M. de Groot, F. Helderman, J. Mo, J. M. A. Daniels, K. Grünberg, T. G. Sutedja, and J. F. de Boer, “High speed miniature motorized endoscopic probe for optical frequency domain imaging,” Opt. Express20(22), 24132–24138 (2012). [CrossRef] [PubMed]
  25. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett.22(5), 340–342 (1997). [CrossRef] [PubMed]
  26. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett.22(22), 1704–1706 (1997). [CrossRef] [PubMed]
  27. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express11(18), 2183–2189 (2003). [CrossRef] [PubMed]
  28. S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett.28(20), 1981–1983 (2003). [CrossRef] [PubMed]
  29. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express11(22), 2953–2963 (2003). [CrossRef] [PubMed]
  30. M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source,” J. Biomed. Opt.10(4), 044009 (2005). [CrossRef] [PubMed]
  31. R. Huber, M. Wojtkowski, K. Taira, J. G. Fujimoto, and K. Hsu, “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles,” Opt. Express13(9), 3513–3528 (2005). [CrossRef] [PubMed]
  32. W. Y. Oh, S. H. Yun, G. J. Tearney, and B. E. Bouma, “115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser,” Opt. Lett.30(23), 3159–3161 (2005). [CrossRef] [PubMed]
  33. R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express14(8), 3225–3237 (2006). [CrossRef] [PubMed]
  34. R. Huber, D. C. Adler, and J. G. Fujimoto, “Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s,” Opt. Lett.31(20), 2975–2977 (2006). [CrossRef] [PubMed]
  35. W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010). [CrossRef] [PubMed]
  36. B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express18(19), 20029–20048 (2010). [CrossRef] [PubMed]
  37. V. Jayaraman, G. D. Cole, M. Robertson, A. Uddin, and A. Cable, “High-sweep-rate 1310 nm MEMS-VCSEL with 150 nm continuous tuning range,” Electron. Lett.48(14), 867–868 (2012). [CrossRef]
  38. I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, J. Jiang, J. G. Fujimoto, and A. E. Cable, “High-precision, high-accuracy ultralong-range swept-source optical coherence tomography using vertical cavity surface emitting laser light source,” Opt. Lett.38(5), 673–675 (2013). [CrossRef] [PubMed]
  39. V. Jayaraman, J. Jiang, H. Li, P. J. S. Heim, G. D. Cole, B. Potsaid, J. G. Fujimoto, and A. Cable, “OCT imaging up to 760 kHz axial scan rate using single-mode 1310nm MEMS-tunable VCSELs with 100nm tuning range,” in Conference on Lasers and Electro-Optics, Technical Digest (CD) (Optical Society of America, 2011), paper PDPB2.
  40. B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Dispersion, coherence and noise of Fourier domain mode locked lasers,” Opt. Express17(12), 9947–9961 (2009). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Multimedia

Multimedia FilesRecommended Software
» Media 1: MPG (3783 KB)      QuickTime
» Media 2: MPG (3722 KB)      QuickTime
» Media 3: MPG (3722 KB)      QuickTime

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited