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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 7 — Jul. 1, 2013
  • pp: 1176–1187

Estimating soft tissue thickness from light-tissue interactions––a simulation study

Tobias Wissel, Ralf Bruder, Achim Schweikard, and Floris Ernst  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 7, pp. 1176-1187 (2013)

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Immobilization and marker-based motion tracking in radiation therapy often cause decreased patient comfort. However, the more comfortable alternative of optical surface tracking is highly inaccurate due to missing point-to-point correspondences between subsequent point clouds as well as elastic deformation of soft tissue. In this study, we present a proof of concept for measuring subcutaneous features with a laser scanner setup focusing on the skin thickness as additional input for high accuracy optical surface tracking. Using Monte-Carlo simulations for multi-layered tissue, we show that informative features can be extracted from the simulated tissue reflection by integrating intensities within concentric ROIs around the laser spot center. Training a regression model with a simulated data set identifies patterns that allow for predicting skin thickness with a root mean square error of down to 18 µm. Different approaches to compensate for varying observation angles were shown to yield errors still below 90 µm. Finally, this initial study provides a very promising proof of concept and encourages research towards a practical prototype.

© 2013 OSA

OCIS Codes
(100.5010) Image processing : Pattern recognition
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(280.0280) Remote sensing and sensors : Remote sensing and sensors
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: May 30, 2013
Manuscript Accepted: June 9, 2013
Published: June 14, 2013

Tobias Wissel, Ralf Bruder, Achim Schweikard, and Floris Ernst, "Estimating soft tissue thickness from light-tissue interactions––a simulation study," Biomed. Opt. Express 4, 1176-1187 (2013)

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