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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 4 — Apr. 1, 2014
  • pp: 1114–1123

Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography

Zach Nadler, Bo Wang, Gadi Wollstein, Jessica E. Nevins, Hiroshi Ishikawa, Richard Bilonick, Larry Kagemann, Ian A. Sigal, R. Daniel Ferguson, Ankit Patel, Daniel X. Hammer, and Joel S. Schuman  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 4, pp. 1114-1123 (2014)
http://dx.doi.org/10.1364/BOE.5.001114


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Abstract

We demonstrate the repeatability of lamina cribrosa (LC) microarchitecture for in vivo 3D optical coherence tomography (OCT) scans of healthy, glaucoma suspects, and glaucomatous eyes. Eyes underwent two scans using a prototype adaptive optics spectral domain OCT (AO-SDOCT) device from which LC microarchitecture was semi-automatically segmented. LC segmentations were used to quantify pore and beam structure through several global microarchitecture parameters. Repeatability of LC microarchitecture was assessed qualitatively and quantitatively by calculating parameter imprecision. For all but one parameters (pore volume) measurement imprecision was <4.7% of the mean value, indicating good measurement reproducibility. Imprecision ranged between 27.3% and 54.5% of the population standard deviation for each parameter, while there was not a significant effect on imprecision due to disease status, indicating utility in testing for LC structural trends.

© 2014 Optical Society of America

OCIS Codes
(100.2000) Image processing : Digital image processing
(110.4500) Imaging systems : Optical coherence tomography
(170.1610) Medical optics and biotechnology : Clinical applications
(170.4470) Medical optics and biotechnology : Ophthalmology
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices

ToC Category:
Image Processing

History
Original Manuscript: November 26, 2013
Revised Manuscript: February 4, 2014
Manuscript Accepted: February 21, 2014
Published: March 10, 2014

Citation
Zach Nadler, Bo Wang, Gadi Wollstein, Jessica E. Nevins, Hiroshi Ishikawa, Richard Bilonick, Larry Kagemann, Ian A. Sigal, R. Daniel Ferguson, Ankit Patel, Daniel X. Hammer, and Joel S. Schuman, "Repeatability of in vivo 3D lamina cribrosa microarchitecture using adaptive optics spectral domain optical coherence tomography," Biomed. Opt. Express 5, 1114-1123 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-4-1114


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