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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 4 — Apr. 1, 2014
  • pp: 1203–1216

Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results

Michelle Agenant, Matthijs Grimbergen, Ronald Draga, Eric Marple, Ruud Bosch, and Christiaan van Swol  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 4, pp. 1203-1216 (2014)

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Abstract: A novel clinical Raman probe for sampling superficial tissue to improve in vivo detection of epithelial malignancies is compared to a non-superficial probe regarding depth response function and signal-to-noise ratio. Depth response measurements were performed in a phantom tissue model consisting of a polyethylene terephthalate disc in an 20%-Intralipid® solution. Sampling ranges of 0-200 and 0-300 μm were obtained for the superficial and non-superficial probe, respectively. The mean signal-to-noise ratio of the superficial probe increased by a factor of 2 compared with the non-superficial probe. This newly developed superficial Raman probe is expected to improve epithelial cancer detection in vivo.

© 2014 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(300.6450) Spectroscopy : Spectroscopy, Raman

ToC Category:
Clinical Instrumentation

Original Manuscript: January 28, 2014
Revised Manuscript: March 10, 2014
Manuscript Accepted: March 10, 2014
Published: March 17, 2014

Michelle Agenant, Matthijs Grimbergen, Ronald Draga, Eric Marple, Ruud Bosch, and Christiaan van Swol, "Clinical superficial Raman probe aimed for epithelial tumor detection: Phantom model results," Biomed. Opt. Express 5, 1203-1216 (2014)

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