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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 4 — Apr. 1, 2014
  • pp: 1275–1289

Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow

Hari M. Varma, Claudia P. Valdes, Anna K. Kristoffersen, Joseph P. Culver, and Turgut Durduran  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 4, pp. 1275-1289 (2014)

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A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of blood flow in deep tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep tissue blood flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of flow using the experimental data obtained from tissue simulating phantoms.

© 2014 Optical Society of America

OCIS Codes
(110.6150) Imaging systems : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.6955) Imaging systems : Tomographic imaging
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Speckle Imaging and Diagnostics

Original Manuscript: January 31, 2014
Revised Manuscript: March 10, 2014
Manuscript Accepted: March 11, 2014
Published: March 28, 2014

Hari M. Varma, Claudia P. Valdes, Anna K. Kristoffersen, Joseph P. Culver, and Turgut Durduran, "Speckle contrast optical tomography: A new method for deep tissue three-dimensional tomography of blood flow," Biomed. Opt. Express 5, 1275-1289 (2014)

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