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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 106–113

Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography

Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen, and Young Jik Kwon  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 1, pp. 106-113 (2010)
http://dx.doi.org/10.1364/BOE.1.000106


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Abstract

Obtaining sufficient contrast is an indispensable requirement for detecting early stage cancer using optical coherence tomography (OCT), an emerging diagnostic tool that detects abnormal lesions with micrometer resolutions in real time. PEGylated gold nanoparticles (Au NPs; 87 nm in diameter) were formulated in aqueous dissolvable microneedles (dMNs; 200 μm height) for efficient, precisely controlled, and convenient delivery of Au NPs into hamster oral tissue in vivo. The Au NPs were then further briefly dissipated by ultrasound (US). The results showed 33% and 20% increase in average optical scattering intensity (contrast level) in dysplastic and normal tissues, respectively, and pinpointed pathological structures of early stage oral cancer were also identified by the highly convenient and efficient administration of Au NPs in a novel delivery platform.

© 2010 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

History
Original Manuscript: June 15, 2010
Manuscript Accepted: July 7, 2010
Published: July 14, 2010

Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express

Citation
Chang Soo Kim, Yeh-Chan Ahn, Petra Wilder-Smith, Seajin Oh, Zhongping Chen, and Young Jik Kwon, "Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography," Biomed. Opt. Express 1, 106-113 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-106


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