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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 126–134

Improved detection limits using a hand-held optical imager with coregistration capabilities

Sarah J. Erickson, Sergio L. Martinez, Jean Gonzalez, Lizeth Caldera, and Anuradha Godavarty  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 1, pp. 126-134 (2010)

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Optical imaging is emerging as a non-invasive and non-ionizing method for breast cancer diagnosis. A hand-held optical imager has been developed with coregistration facilities towards flexible imaging of different tissue volumes and curvatures in near real-time. Herein, fluorescence-enhanced optical imaging experiments are performed to demonstrate deeper target detection under perfect and imperfect (100:1) uptake conditions in (liquid) tissue phantoms and in vitro. Upon summation of multiple scans (fluorescence intensity images), fluorescent targets are detected at greater depths than from single scan alone.

© 2010 OSA

OCIS Codes
(110.2970) Imaging systems : Image detection systems
(110.3080) Imaging systems : Infrared imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.0113) Imaging systems : Imaging through turbid media
(110.6955) Imaging systems : Tomographic imaging

ToC Category:
Clinical Instrumentation

Original Manuscript: June 1, 2010
Revised Manuscript: July 10, 2010
Manuscript Accepted: July 12, 2010
Published: July 15, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Sarah J. Erickson, Sergio L. Martinez, Jean Gonzalez, Lizeth Caldera, and Anuradha Godavarty, "Improved detection limits using a hand-held optical imager with coregistration capabilities," Biomed. Opt. Express 1, 126-134 (2010)

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  1. S. J. Erickson and A. Godavarty, “Hand-held based near-infrared optical imaging devices: a review,” Med. Eng. Phys. 31(5), 495–509 (2009). [CrossRef] [PubMed]
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