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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 17–30

Fiber-optic Raman probe couples ball lens for depth-selected Raman measurements of epithelial tissue

Jianhua Mo, Wei Zheng, and Zhiwei Huang  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 1, pp. 17-30 (2010)
http://dx.doi.org/10.1364/BOE.1.000017


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Abstract

In this study, we present a fiber-optic ball lens Raman probe design for improving depth-selected Raman measurements of epithelial tissue. The Monte Carlo simulation results show that tissue Raman collection efficiency can be improved by properly selecting the refractive index and the diameter of the ball lens for the Raman probe design and the depth-selectivity of Raman measurements can also be improved by either increasing the refractive index or reducing the diameter of the ball lens. An appropriate arrangement of the Raman probe-tissue distance can also optimize the collection efficiency for depth-resolved Raman measurements. Experimental evaluation of a ball lens Raman probe design on a two-layer tissue phantom confirms the potential of the ball lens Raman probe design for efficient depth-selected measurement on epithelial tissue. This work suggests that the fiber-optic Raman probe coupled with a ball lens can facilitate the depth-selected Raman measurements of epithelial tissue, which may improve the diagnosis of epithelial precancer and early cancer at the molecular level.

© 2010 OSA

OCIS Codes
(120.4570) Instrumentation, measurement, and metrology : Optical design of instruments
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy

ToC Category:
Tissue Optics and Spectroscopy

History
Original Manuscript: May 4, 2010
Revised Manuscript: June 15, 2010
Manuscript Accepted: June 15, 2010
Published: June 28, 2010

Citation
Jianhua Mo, Wei Zheng, and Zhiwei Huang, "Fiber-optic Raman probe couples ball lens for depth-selected Raman measurements of epithelial tissue," Biomed. Opt. Express 1, 17-30 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-17


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References

  1. N. Stone, C. Kendall, N. Shepherd, P. Crow, and H. Barr, “Near-infrared Raman spectroscopy for the classification of epithelial pre-cancers and cancers,” J. Raman Spectrosc. 33(7), 564–573 (2002). [CrossRef]
  2. Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, “Near-infrared Raman spectroscopy for optical diagnosis of lung cancer,” Int. J. Cancer 107(6), 1047–1052 (2003). [CrossRef] [PubMed]
  3. Z. Huang, H. Zeng, I. Hamzavi, D. I. McLean, and H. Lui, “Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements,” Opt. Lett. 26(22), 1782–1784 (2001). [CrossRef] [PubMed]
  4. M. G. Shim, B. C. Wilson, E. Marple, and M. Wach, “Study of fiber-optic probes for in vivo medical Raman spectroscopy,” Appl. Spectrosc. 53(6), 619–627 (1999). [CrossRef]
  5. Z. Huang, S. K. Teh, W. Zheng, J. Mo, K. Lin, X. Shao, K. Y. Ho, M. Teh, and K. G. Yeoh, “Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy,” Opt. Lett. 34(6), 758–760 (2009). [CrossRef] [PubMed]
  6. R. Drezek, C. Brookner, I. Pavlova, I. Boiko, A. Malpica, R. Lotan, M. Follen, and R. Richards-Kortum, “Autofluorescence microscopy of fresh cervical-tissue sections reveals alterations in tissue biochemistry with dysplasia,” Photochem. Photobiol. 73(6), 636–641 (2001). [CrossRef] [PubMed]
  7. F. W. Abdul-Karim, Y. S. Fu, J. W. Reagan, and W. B. Wentz, “Morphometric study of intraepithelial neoplasia of the uterine cervix,” Obstet. Gynecol. 60(2), 210–214 (1982). [PubMed]
  8. J. Mo, W. Zheng, J. J. H. Low, J. Ng, A. Ilancheran, and Z. Huang, “High wavenumber Raman spectroscopy for in vivo detection of cervical dysplasia,” Anal. Chem. 81(21), 8908–8915 (2009). [CrossRef] [PubMed]
  9. W. C. Shih, K. L. Bechtel, and M. S. Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy part I: theory and simulations,” Opt. Express 16(17), 12726–12736 (2008). [PubMed]
  10. T. J. Pfefer, K. T. Schomacker, M. N. Ediger, and N. S. Nishioka, “Light propagation in tissue during fluorescence spectroscopy with single-fiber probes,” IEEE Sel. Top. Quantum Electron. 7(6), 1004–1012 (2001). [CrossRef]
  11. T. J. Pfefer, K. T. Schomacker, M. N. Ediger, and N. S. Nishioka, “Multiple-fiber probe design for fluorescence spectroscopy in tissue,” Appl. Opt. 41(22), 4712–4721 (2002). [CrossRef] [PubMed]
  12. L. Nieman, A. Myakov, J. Aaron, and K. Sokolov, “Optical sectioning using a fiber probe with an angled illumination-collection geometry: evaluation in engineered tissue phantoms,” Appl. Opt. 43(6), 1308–1319 (2004). [CrossRef] [PubMed]
  13. R. A. Schwarz, D. Arifler, S. K. Chang, I. Pavlova, I. A. Hussain, V. Mack, B. Knight, R. Richards-Kortum, and A. M. Gillenwater, “Ball lens coupled fiber-optic probe for depth-resolved spectroscopy of epithelial tissue,” Opt. Lett. 30(10), 1159–1161 (2005). [CrossRef] [PubMed]
  14. F. Jaillon, W. Zheng, and Z. Huang, “Beveled fiber-optic probe couples a ball lens for improving depth-resolved fluorescence measurements of layered tissue: Monte Carlo simulations,” Phys. Med. Biol. 53(4), 937–951 (2008). [CrossRef] [PubMed]
  15. F. Jaillon, W. Zheng, and Z. Huang, “Half-ball lens couples a beveled fiber probe for depth-resolved spectroscopy: Monte Carlo simulations,” Appl. Opt. 47(17), 3152–3157 (2008). [CrossRef] [PubMed]
  16. J. T. Motz, M. Hunter, L. H. Galindo, J. A. Gardecki, J. R. Kramer, R. R. Dasari, and M. S. Feld, “Optical fiber probe for biomedical Raman spectroscopy,” Appl. Opt. 43(3), 542–554 (2004). [CrossRef] [PubMed]
  17. L. Wang, S. L. Jacques, and L. Zheng, “MCML--Monte Carlo modeling of light transport in multi-layered tissues,” Comput. Methods Programs Biomed. 47(2), 131–146 (1995). [CrossRef] [PubMed]
  18. A. J. Welch, C. Gardner, R. Richards-Kortum, E. Chan, G. Criswell, J. Pfefer, and S. Warren, “Propagation of fluorescent light,” Lasers Surg. Med. 21(2), 166–178 (1997). [CrossRef] [PubMed]
  19. G. M. Palmer and N. Ramanujam, “Monte-Carlo-based model for the extraction of intrinsic fluorescence from turbid media,” J. Biomed. Opt. 13(2), 024017–024019 (2008). [CrossRef] [PubMed]
  20. W. C. Shih, K. L. Bechtel, and M. S. Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy part I: theory and simulations,” Opt. Express 16(17), 12726–12736 (2008). [PubMed]
  21. K. L. Bechtel, W. C. Shih, and M. S. Feld, “Intrinsic Raman spectroscopy for quantitative biological spectroscopy part II: experimental applications,” Opt. Express 16(17), 12737–12745 (2008). [PubMed]
  22. L. G. Henyey and J. L. Greenstein, “Diffuse radiation in galaxy,” Astrophys. J. 93, 70–83 (1941). [CrossRef]
  23. M. J. Riedl, Optical design fundamentals for infrared systems (SPIE Press, Bellingham, Wash., 2001).
  24. S. K. Chang, D. Arifler, R. Drezek, M. Follen, and R. Richards-Kortum, “Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements,” J. Biomed. Opt. 9(3), 511–522 (2004). [CrossRef] [PubMed]

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