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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 223–235

Compositional-prior-guided image reconstruction algorithm for multi-modality imaging

Qianqian Fang, Richard H. Moore, Daniel B. Kopans, and David A. Boas  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 1, pp. 223-235 (2010)
http://dx.doi.org/10.1364/BOE.1.000223


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Abstract

The development of effective multi-modality imaging methods typically requires an efficient information fusion model, particularly when combining structural images with a complementary imaging modality that provides functional information. We propose a composition-based image segmentation method for X-ray digital breast tomosynthesis (DBT) and a structural-prior-guided image reconstruction for a combined DBT and diffuse optical tomography (DOT) breast imaging system. Using the 3D DBT images from 31 clinically measured healthy breasts, we create an empirical relationship between the X-ray intensities for adipose and fibroglandular tissue. We use this relationship to then segment another 58 healthy breast DBT images from 29 subjects into compositional maps of different tissue types. For each breast, we build a weighted-graph in the compositional space and construct a regularization matrix to incorporate the structural priors into a finite-element-based DOT image reconstruction. Use of the compositional priors enables us to fuse tissue anatomy into optical images with less restriction than when using a binary segmentation. This allows us to recover the image contrast captured by DOT but not by DBT. We show that it is possible to fine-tune the strength of the structural priors by changing a single regularization parameter. By estimating the optical properties for adipose and fibroglandular tissue using the proposed algorithm, we found the results are comparable or superior to those estimated with expert-segmentations, but does not involve the time-consuming manual selection of regions-of-interest.

© 2010 OSA

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(100.3190) Image processing : Inverse problems
(170.3830) Medical optics and biotechnology : Mammography
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Optics in Cancer Research

History
Original Manuscript: June 2, 2010
Revised Manuscript: July 10, 2010
Manuscript Accepted: July 13, 2010
Published: July 16, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Citation
Qianqian Fang, Richard H. Moore, Daniel B. Kopans, and David A. Boas, "Compositional-prior-guided image reconstruction algorithm for multi-modality imaging," Biomed. Opt. Express 1, 223-235 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-1-223


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