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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 295–309

Near infrared transillumination imaging of breast cancer with vasoactive inhalation contrast

Sanhita S. Dixit, Hanyoup Kim, Christopher Comstock, and Gregory W. Faris  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 1, pp. 295-309 (2010)

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Inhalation of vasoactive gases such as carbon dioxide and oxygen can provide strong changes in tissue hemodynamics. In this report, we present a preliminary clinical study aimed at assessing the feasibility of inhalation-based contrast with near infrared continuous wave transillumination for breast imaging. We describe a method for fitting the transient absorbance that provides the wavelength dependence of the optical pathlength as parametrized by tissue oxygenation and scatter power as well as the differential changes in oxy- and deoxy-hemoglobin. We also present a principal component analysis data reduction technique to assess the dynamic response from the tissue that uses coercion to provide single temporal eigenvalues associated with both oxy- and deoxy-hemoglobin changes.

© 2010 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3830) Medical optics and biotechnology : Mammography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optics in Cancer Research

Original Manuscript: June 21, 2010
Revised Manuscript: July 17, 2010
Manuscript Accepted: August 20, 2010
Published: July 27, 2010

Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express

Sanhita S. Dixit, Hanyoup Kim, Christopher Comstock, and Gregory W. Faris, "Near infrared transillumination imaging of breast cancer with vasoactive inhalation contrast," Biomed. Opt. Express 1, 295-309 (2010)

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