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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 1 — Aug. 2, 2010
  • pp: 310–317

Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics

Francisco E. Robles, Shwetadwip Chowdhury, and Adam Wax  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 1, pp. 310-317 (2010)

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Hemoglobin (Hb) concentration and oxygen saturation levels are important biomarkers for various diseases, including cancer. Here, we investigate the ability to measure these parameters for tissue using spectroscopic optical coherence tomography (SOCT). A parallel frequency domain OCT system is used with detection spanning the visible region of the spectrum (450 nm to 700 nm). Oxygenated and deoxygenated Hb absorbing phantoms are analyzed. The results show that Hb concentrations as low as 1.2 g/L at 1 mm can be retrieved indicating that both normal and cancerous tissue measurements may be obtained. However, measurement of oxygen saturation levels may not be achieved with this approach.

© 2010 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.1030) Spectroscopy : Absorption

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: June 1, 2010
Revised Manuscript: July 16, 2010
Manuscript Accepted: July 16, 2010
Published: July 27, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Francisco E. Robles, Shwetadwip Chowdhury, and Adam Wax, "Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics," Biomed. Opt. Express 1, 310-317 (2010)

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