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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 2 — Sep. 1, 2010
  • pp: 425–430

A tissue equivalent phantom for simultaneous near-infrared optical tomography and EEG

R. J. Cooper, R. Eames, J. Brunker, L. C. Enfield, A. P. Gibson, and Jeremy C Hebden  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 2, pp. 425-430 (2010)

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We describe a phantom which enables EEG and near-infrared optical tomography to be performed simultaneously over the same volume. The phantom provides a surface electrical contact impedance comparable to that of the human scalp, whilst also possessing an optical scattering coefficient and electrical conductivity equivalent to that of brain tissue. The construction of the phantom is described, as is the resulting simultaneous EEG and near infrared optical tomography experiment, which, to our knowledge, is the first performed on a scale comparable to that of the infant human brain. This imaging experiment successfully shows the suitability of this phantom construction for the assessment of simultaneous EEG and near infrared optical tomography systems.

© 2010 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Calibration, Validation and Phantom Studies

Original Manuscript: June 1, 2010
Revised Manuscript: July 14, 2010
Manuscript Accepted: July 23, 2010
Published: August 2, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

R. J. Cooper, R. Eames, J. Brunker, L. C. Enfield, A. P. Gibson, and Jeremy C Hebden, "A tissue equivalent phantom for simultaneous near-infrared optical tomography and EEG," Biomed. Opt. Express 1, 425-430 (2010)

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  1. J. Gotman, E. Kobayashi, A. P. Bagshaw, C. G. Bénar, and F. Dubeau, “Combining EEG and fMRI: a multimodal tool for epilepsy research,” J. Magn. Reson. Imaging 23(6), 906–920 (2006). [CrossRef] [PubMed]
  2. R. I. Goldman, J. M. Stern, J. Engel, and M. S. Cohen, “Simultaneous EEG and fMRI of the alpha rhythm,” Neuroreport 13(18), 2487–2492 (2002). [CrossRef] [PubMed]
  3. H. Obrig, H. Israel, M. Kohl-Bareis, K. Uludag, R. Wenzel, B. Müller, G. Arnold, and A. Villringer, “Habituation of the visually evoked potential and its vascular response: implications for neurovascular coupling in the healthy adult,” Neuroimage 17(1), 1–18 (2002). [CrossRef] [PubMed]
  4. S. P. Koch, J. Steinbrink, A. Villringer, and H. Obrig, “Synchronization between background activity and visually evoked potential is not mirrored by focal hyperoxygenation: implications for the interpretation of vascular brain imaging,” J. Neurosci. 26(18), 4940–4948 (2006). [CrossRef] [PubMed]
  5. M. C. Toet and P. M. Lemmers, “Brain monitoring in neonates,” Early Hum. Dev. 85(2), 77–84 (2009). [CrossRef] [PubMed]
  6. F. Wallois, A. Patil, G. Kongolo, S. Goudjil, and R. Grebe, “Haemodynamic changes during seizure-like activity in a neonate: a simultaneous AC EEG-SPIR and high-resolution DC EEG recording,” Neurophysiol. Clin. 39(4-5), 217–227 (2009). [CrossRef] [PubMed]
  7. M. S. Scher, “Neonatal seizures and brain damage,” Pediatr. Neurol. 29(5), 381–390 (2003). [CrossRef] [PubMed]
  8. A. P. Gibson, T. Austin, N. L. Everdell, M. Schweiger, S. R. Arridge, J. H. Meek, J. S. Wyatt, D. T. Delpy, and J. C. Hebden, “Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate,” Neuroimage 30(2), 521–528 (2006). [CrossRef] [PubMed]
  9. R. J. Cooper, N. L. Everdell, L. C. Enfield, A. P. Gibson, A. Worley, and J. C. Hebden, “Design and evaluation of a probe for simultaneous EEG and near-infrared imaging of cortical activation,” Phys. Med. Biol. 54(7), 2093–2102 (2009). [CrossRef] [PubMed]
  10. B. W. Pogue and M. S. Patterson, “Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry,” J. Biomed. Opt. 11(4), 041102 (2006). [CrossRef] [PubMed]
  11. R. J. Cooper, D. Bhatt, N. L. Everdell, and J. C. Hebden, “A tissue-like optically turbid and electrically conducting phantom for simultaneous EEG and near-infrared imaging,” Phys. Med. Biol. 54(18), 403–408 (2009). [CrossRef]
  12. T. Tidswell, A. Gibson, R. H. Bayford, and D. S. Holder, “Three-dimensional electrical impedance tomography of human brain activity,” Neuroimage 13(2), 283–294 (2001). [CrossRef] [PubMed]
  13. F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, and D. T. Delpy, “A 32-channel time-resolved instrument for medical optical tomography,” Rev. Sci. Instrum. 71(1), 256–265 (2000). [CrossRef]
  14. S. R. Arridge, J. C. Hebden, M. Schweiger, F. E. Schmidt, M. E. Fry, E. M. Hillman, H. Dehghani, and D. T. Delpy, “A method for three-dimensional time-resolved optical tomography,” Int. J. Imaging Syst. Technol. 11(1), 2–11 (2000). [CrossRef]

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