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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 2 — Sep. 1, 2010
  • pp: 489–499

Analysis of pressure, angle and temporal effects on tissue optical properties from polarization-gated spectroscopic probe measurements

Sarah Ruderman, Andrew J. Gomes, Valentina Stoyneva, Jeremy D. Rogers, Angela J. Fought, Borko D. Jovanovic, and Vadim Backman  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 2, pp. 489-499 (2010)

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Noninvasive optical techniques for tissue characterization, in particular, light scattering properties and blood supply quantification of mucosa, is useful in a wide variety of applications. However, fiber-optic probes that require contact with the tissue surface can present a challenging problem in the variability of in vivo measurements due the nature of interactions, for example affects due to variations in pressure applied to the probe tip. We present an in vivo evaluation of pressure, angle, and temporal effects on tissue properties for polarization-gated spectroscopy at superficial depths (within 100 to 200 microns of tissue surface) for oral mucosa.

© 2010 OSA

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(220.4840) Optical design and fabrication : Testing
(300.0300) Spectroscopy : Spectroscopy
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: June 2, 2010
Revised Manuscript: July 24, 2010
Manuscript Accepted: August 2, 2010
Published: August 5, 2010

Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express

Sarah Ruderman, Andrew J. Gomes, Valentina Stoyneva, Jeremy D. Rogers, Angela J. Fought, Borko D. Jovanovic, and Vadim Backman, "Analysis of pressure, angle and temporal effects on tissue optical properties from polarization-gated spectroscopic probe measurements," Biomed. Opt. Express 1, 489-499 (2010)

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