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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 2 — Sep. 1, 2010
  • pp: 512–526

Algorithms for bioluminescence tomography incorporating anatomical information and reconstruction of tissue optical properties

Mohamed A. Naser and Michael S. Patterson  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 2, pp. 512-526 (2010)
http://dx.doi.org/10.1364/BOE.1.000512


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Abstract

Reconstruction algorithms are presented for a two-step solution of the bioluminescence tomography (BLT) problem. In the first step, a priori anatomical information provided by x-ray computed tomography or by other methods is used to solve the continuous wave (cw) diffuse optical tomography (DOT) problem. A Taylor series expansion approximates the light fluence rate dependence on the optical properties of each region where first and second order direct derivatives of the light fluence rate with respect to scattering and absorption coefficients are obtained and used for the reconstruction. In the second step, the reconstructed optical properties at different wavelengths are used to calculate the Green’s function of the system. Then an iterative minimization solution based on the L1 norm shrinks the permissible regions where the sources are allowed by selecting points with higher probability to contribute to the source distribution. This provides an efficient BLT reconstruction algorithm with the ability to determine relative source magnitudes and positions in the presence of noise.

© 2010 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Image Reconstruction and Inverse Problems

History
Original Manuscript: July 8, 2010
Revised Manuscript: July 30, 2010
Manuscript Accepted: August 2, 2010
Published: August 5, 2010

Citation
Mohamed A. Naser and Michael S. Patterson, "Algorithms for bioluminescence tomography incorporating anatomical information and reconstruction of tissue optical properties," Biomed. Opt. Express 1, 512-526 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-2-512


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