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Validation of diffuse correlation spectroscopy measurements of rodent cerebral blood flow with simultaneous arterial spin labeling MRI; towards MRI-optical continuous cerebral metabolic monitoringS. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim »View Author Affiliations
S. A. Carp,1,*
G. P. Dai,1
D. A. Boas,1
M. A. Franceschini,1
and Y. R. Kim1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA *Corresponding author: carp@nmr.mgh.harvard.edu |
Biomedical Optics Express, Vol. 1, Issue 2, pp. 553-565 (2010)
http://dx.doi.org/10.1364/BOE.1.000553
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Abstract
Cerebral blood flow (CBF) during stepped hypercapnia was measured simultaneously in the rat brain using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeling MRI (ASL). DCS and ASL CBF values agree very well, with high correlation (R=0.86, p< 10-9), even when physiological instability perturbed the vascular response. A partial volume effect was evident in the smaller magnitude of the optical CBF response compared to the MRI values (averaged over the cortical area), primarily due to the inclusion of white matter in the optically sampled volume. The 8.2 and 11.7 mm mid-separation channels of the multi-distance optical probe had the lowest partial volume impact, reflecting ~75 % of the MR signal change. Using a multiplicative correction factor, the ASL CBF could be predicted with no more than 10% relative error, affording an opportunity for real-time relative cerebral metabolism monitoring in conjunction with MR measurement of cerebral blood volume using super paramagnetic contrast agents.
© 2010 Optical Society of America
OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Neuroscience and Brain Imaging
History
Original Manuscript: June 1, 2010
Revised Manuscript: July 13, 2010
Manuscript Accepted: July 13, 2010
Published: August 10, 2010
Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express
Citation
S. A. Carp, G. P. Dai, D. A. Boas, M. A. Franceschini, and Y. R. Kim, "Validation of diffuse correlation spectroscopy measurements of rodent
cerebral blood flow with simultaneous arterial spin labeling MRI; towards
MRI-optical continuous cerebral metabolic monitoring," Biomed. Opt. Express 1, 553-565 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-2-553
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Buxton, R. B.
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- N. Roche-Labarbe, S. A. Carp, A. Surova, M. Patel, D. A. Boas, P. E. Grant, and M. A. Franceschini, “Noninvasive optical measures of CBV, StO2, CBF index, and rCMRO2 in human premature neonates’ brains in the first six weeks of life,” Hum. Brain Mapp. 31, 341–352 (2010).
- J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
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