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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 2 — Sep. 1, 2010
  • pp: 641–657

Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia

José-Miguel Yamal, Dennis D. Cox, E. Neely Atkinson, Calum MacAulay, Roderick Price, and Michele Follen  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 2, pp. 641-657 (2010)
http://dx.doi.org/10.1364/BOE.1.000641


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Abstract

We examined intensity and shape differences in 378 repeated spectroscopic measures of the cervix. We examined causes of variability such as presence of precancer or cancer, pathologic tissue type, menopausal status, hormone or oral contraceptive use, and age; as well as technology related variables like generation of device and provider making exam. Age, device generation, and provider were statistically significantly related to intensity differences. Provider and device generation were related to shape differences. We examined the order of measurements and found a decreased intensity in the second measurement due to hemoglobin absorption. 96% of repeat measurements had classification concordance of cervical intraepithelial neoplasia.

© 2010 OSA

OCIS Codes
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Optics in Cancer Research

History
Original Manuscript: June 2, 2010
Revised Manuscript: August 5, 2010
Manuscript Accepted: August 17, 2010
Published: August 19, 2010

Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express

Citation
José-Miguel Yamal, Dennis D. Cox, E. Neely Atkinson, Calum MacAulay, Roderick Price, and Michele Follen, "Repeatability of tissue fluorescence measurements for the detection of cervical intraepithelial neoplasia," Biomed. Opt. Express 1, 641-657 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-2-641


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References

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