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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 1014–1025

Detection of colonic inflammation with Fourier transform infrared spectroscopy using a flexible silver halide fiber

Vinay K. Katukuri, John Hargrove, Sharon J. Miller, Kinan Rahal, John Y. Kao, Rolf Wolters, Ellen M. Zimmermann, and Thomas D. Wang  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 3, pp. 1014-1025 (2010)
http://dx.doi.org/10.1364/BOE.1.001014


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Abstract

Persistent colonic inflammation increases risk for cancer, but mucosal appearance on conventional endoscopy correlates poorly with histology. Here we demonstrate the use of a flexible silver halide fiber to collect mid-infrared absorption spectra and an interval model to distinguish colitis from normal mucosa in dextran sulfate sodium treated mice. The spectral regime between 950 and 1800 cm−1 was collected from excised colonic specimens and compared with histology. Our model identified 3 sub-ranges that optimize the classification results, and the performance for detecting inflammation resulted in a sensitivity, specificity, accuracy, and positive predictive value of 92%, 88%, 90%, and 88%, respectively.

© 2010 OSA

OCIS Codes
(070.4790) Fourier optics and signal processing : Spectrum analysis
(070.5010) Fourier optics and signal processing : Pattern recognition
(110.2350) Imaging systems : Fiber optics imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(300.6300) Spectroscopy : Spectroscopy, Fourier transforms

ToC Category:
Optics in Cancer Research

History
Original Manuscript: July 30, 2010
Revised Manuscript: September 16, 2010
Manuscript Accepted: September 19, 2010
Published: September 21, 2010

Citation
Vinay K. Katukuri, John Hargrove, Sharon J. Miller, Kinan Rahal, John Y. Kao, Rolf Wolters, Ellen M. Zimmermann, and Thomas D. Wang, "Detection of colonic inflammation with Fourier transform infrared spectroscopy using a flexible silver halide fiber," Biomed. Opt. Express 1, 1014-1025 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-3-1014


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