Optics InfoBase > Biomedical Optics Express > Volume 1 > Issue 3 > Page 780
|
|
Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applicationsSean A. Burgess, Désirée Ratner, Brenda R. Chen, and Elizabeth M. C. Hillman »View Author Affiliations
Sean A. Burgess,1,*
Désirée Ratner,2
Brenda R. Chen,1
and Elizabeth M. C. Hillman1
1Laboratory for Functional Optical Imaging, Departments of Biomedical Engineering and Radiology, Columbia University, New York, NY 10027, USA 2Department of Dermatology, Columbia University Medical Center, New York, NY 10027, USA *Corresponding author: sab2161@columbia.edu |
Biomedical Optics Express, Vol. 1, Issue 3, pp. 780-790 (2010)
http://dx.doi.org/10.1364/BOE.1.000780
View Full Text Article
Enhanced HTML
Acrobat PDF (1543 KB)
Abstract
Laminar optical tomography (LOT) is a recently developed technique for depth-resolved in vivo imaging of absorption and fluorescence contrast. Until now, LOT has been implemented in a benchtop configuration, limiting accessibility to tissues and restricting imaging applications. Here we report on LOT implemented through an articulating arm and a fiber optic image bundle allowing flexible imaging for a range of clinical applications. We quantify the performance of these two implementations by imaging a tissue mimicking phantom.
© 2010 OSA
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
ToC Category:
Clinical Instrumentation
History
Original Manuscript: June 4, 2010
Revised Manuscript: August 28, 2010
Manuscript Accepted: August 31, 2010
Published: September 2, 2010
Virtual Issues
Bio-Optics in Clinical Application, Nanotechnology, and Drug Discovery (2010) Biomedical Optics Express
Citation
Sean A. Burgess, Désirée Ratner, Brenda R. Chen, and Elizabeth M. C. Hillman, "Fiber-optic and articulating arm implementations of laminar optical tomography for clinical applications," Biomed. Opt. Express 1, 780-790 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-3-780
Sort: Author | Year | Journal | Reset
References
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- M. Rajadhyaksha, R. R. Anderson, and R. H. Webb, “Video-rate confocal scanning laser microscope for imaging human tissues in vivo,” Appl. Opt. 38(10), 2105–2115 (1999). [CrossRef] [PubMed]
- E. M. C. Hillman, O. Bernus, E. Pease, M. B. Bouchard, and A. Pertsov, “Depth-resolved optical imaging of transmural electrical propagation in perfused heart,” Opt. Express 15(26), 17827–17841 (2007). [CrossRef] [PubMed]
- E. M. C. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, “Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media,” Opt. Lett. 29(14), 1650–1652 (2004). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
- N. Ouakli, E. Guevara, S. Dubeau, É. Beaumont, and F. Lesage, “Laminar optical tomography of the hemodynamic response in the lumbar spinal cord of rats,” Opt. Express 18(10), 10068–10077 (2010). [CrossRef] [PubMed]
- S. Yuan, Q. Li, J. Jiang, A. Cable, and Y. Chen, “Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography,” Opt. Lett. 34(11), 1615–1617 (2009). [CrossRef] [PubMed]
- E. M. C. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- F. C. Allard, Fiber optics handbook: for engineers and scientists, Optical and electro-optical engineering series (McGraw-Hill, New York, 1990), p. 549 p. in various pagings.
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- E. M. C. Hillman and S. A. Burgess, “Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography,” Laser Photon Rev 3(1-2), 159–179 (2009). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
- E. M. C. Hillman, O. Bernus, E. Pease, M. B. Bouchard, and A. Pertsov, “Depth-resolved optical imaging of transmural electrical propagation in perfused heart,” Opt. Express 15(26), 17827–17841 (2007). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- E. M. C. Hillman and S. A. Burgess, “Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography,” Laser Photon Rev 3(1-2), 159–179 (2009). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- E. M. C. Hillman and S. A. Burgess, “Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography,” Laser Photon Rev 3(1-2), 159–179 (2009). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
- E. M. C. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007). [CrossRef] [PubMed]
- E. M. C. Hillman, O. Bernus, E. Pease, M. B. Bouchard, and A. Pertsov, “Depth-resolved optical imaging of transmural electrical propagation in perfused heart,” Opt. Express 15(26), 17827–17841 (2007). [CrossRef] [PubMed]
- E. M. C. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, “Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media,” Opt. Lett. 29(14), 1650–1652 (2004). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
Appl. Opt.
- M. Rajadhyaksha, R. R. Anderson, and R. H. Webb, “Video-rate confocal scanning laser microscope for imaging human tissues in vivo,” Appl. Opt. 38(10), 2105–2115 (1999). [CrossRef] [PubMed]
BJOG
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
Br. J. Dermatol.
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
Cancer
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
Clin. Gastroenterol. Hepatol.
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
Eur. Arch. Otorhinolaryngol.
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
Gastroenterology
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
Gastrointest. Endosc.
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
IEEE Trans. Biomed. Eng.
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
J. Biomed. Opt.
- E. M. C. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
Laser Photon Rev
- E. M. C. Hillman and S. A. Burgess, “Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography,” Laser Photon Rev 3(1-2), 159–179 (2009). [CrossRef] [PubMed]
Lasers Surg. Med.
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
Opt. Express
- N. Ouakli, E. Guevara, S. Dubeau, É. Beaumont, and F. Lesage, “Laminar optical tomography of the hemodynamic response in the lumbar spinal cord of rats,” Opt. Express 18(10), 10068–10077 (2010). [CrossRef] [PubMed]
- K. B. Sung, R. Richards-Kortum, M. Follen, A. Malpica, C. Liang, and M. Descour, “Fiber optic confocal reflectance microscopy: a new real-time technique to view nuclear morphology in cervical squamous epithelium in vivo,” Opt. Express 11(24), 3171–3181 (2003). [CrossRef] [PubMed]
- E. M. C. Hillman, O. Bernus, E. Pease, M. B. Bouchard, and A. Pertsov, “Depth-resolved optical imaging of transmural electrical propagation in perfused heart,” Opt. Express 15(26), 17827–17841 (2007). [CrossRef] [PubMed]
Opt. Lett.
- E. M. C. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, “Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media,” Opt. Lett. 29(14), 1650–1652 (2004). [CrossRef] [PubMed]
- S. A. Burgess, M. B. Bouchard, B. Yuan, and E. M. C. Hillman, “Simultaneous multiwavelength laminar optical tomography,” Opt. Lett. 33(22), 2710–2712 (2008). [CrossRef] [PubMed]
- S. Yuan, Q. Li, J. Jiang, A. Cable, and Y. Chen, “Three-dimensional coregistered optical coherence tomography and line-scanning fluorescence laminar optical tomography,” Opt. Lett. 34(11), 1615–1617 (2009). [CrossRef] [PubMed]
Phys. Med. Biol.
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
Rev. Sci. Instrum.
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
Scanning
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
Other
- F. C. Allard, Fiber optics handbook: for engineers and scientists, Optical and electro-optical engineering series (McGraw-Hill, New York, 1990), p. 549 p. in various pagings.
2010, Haxel, Eur. Arch. Otorhinolaryngol.
- B. R. Haxel, M. Goetz, R. Kiesslich, and J. Gosepath, “Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human,” Eur. Arch. Otorhinolaryngol. 267(3), 443–448 (2010). [CrossRef] [PubMed]
- P. M. Lane, S. Lam, A. McWilliams, J. C. Leriche, M. W. Anderson, and C. E. Macaulay, “Confocal fluorescence microendoscopy of bronchial epithelium,” J. Biomed. Opt. 14(2), 024008 (2009). [CrossRef] [PubMed]
- B. Yuan, S. A. Burgess, A. Iranmahboob, M. B. Bouchard, N. Lehrer, C. Bordier, and E. M. C. Hillman, “A system for high-resolution depth-resolved optical imaging of fluorescence and absorption contrast,” Rev. Sci. Instrum. 80(4), 043706 (2009). [CrossRef] [PubMed]
- R. A. Schwarz, W. Gao, C. Redden Weber, C. Kurachi, J. J. Lee, A. K. El-Naggar, R. Richards-Kortum, and A. M. Gillenwater, “Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy,” Cancer 115(8), 1669–1679 (2009). [CrossRef] [PubMed]
- J. Tan, M. A. Quinn, J. M. Pyman, P. M. Delaney, and W. J. McLaren, “Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopy,” BJOG 116(12), 1663–1670 (2009). [CrossRef] [PubMed]
- J. de Leeuw, N. van der Beek, W. D. Neugebauer, P. Bjerring, and H. A. Neumann, “Fluorescence detection and diagnosis of non-melanoma skin cancer at an early stage,” Lasers Surg. Med. 41(2), 96–103 (2009). [CrossRef] [PubMed]
- K. B. Dunbar, P. Okolo, E. Montgomery, and M. I. Canto, “Confocal laser endomicroscopy in Barrett’s esophagus and endoscopically inapparent Barrett’s neoplasia: a prospective, randomized, double-blind, controlled, crossover trial,” Gastrointest. Endosc. 70(4), 645–654 (2009). [CrossRef] [PubMed]
- E. M. C. Hillman and S. A. Burgess, “Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography,” Laser Photon Rev 3(1-2), 159–179 (2009). [CrossRef] [PubMed]
- E. M. C. Hillman, “Optical brain imaging in vivo: techniques and applications from animal to man,” J. Biomed. Opt. 12(5), 051402 (2007). [CrossRef] [PubMed]
- R. Kiesslich, L. Gossner, M. Goetz, A. Dahlmann, M. Vieth, M. Stolte, A. Hoffman, M. Jung, B. Nafe, P. R. Galle, and M. F. Neurath, “In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy,” Clin. Gastroenterol. Hepatol. 4(8), 979–987 (2006). [CrossRef] [PubMed]
- B. Stenquist, M. B. Ericson, C. Strandeberg, L. Mölne, A. Rosén, O. Larkö, and A. M. Wennberg, “Bispectral fluorescence imaging of aggressive basal cell carcinoma combined with histopathological mapping: a preliminary study indicating a possible adjunct to Mohs micrographic surgery,” Br. J. Dermatol. 154(2), 305–309 (2006). [CrossRef] [PubMed]
- M. Lualdi, A. Colombo, M. Carrara, L. Scienza, S. Tomatis, and R. Marchesini, “Optical devices used for image analysis of pigmented skin lesions: a proposal for quality assurance protocol using tissue-like phantoms,” Phys. Med. Biol. 51(23), N429–N440 (2006). [CrossRef] [PubMed]
- R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology 127(3), 706–713 (2004). [CrossRef] [PubMed]
- K. B. Sung, C. Liang, M. Descour, T. Collier, M. Follen, and R. Richards-Kortum, “Fiber-optic confocal reflectance microscope with miniature objective for in vivo imaging of human tissues,” IEEE Trans. Biomed. Eng. 49(10), 1168–1172 (2002). [CrossRef] [PubMed]
- R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “A solid tissue phantom for photon migration studies,” Phys. Med. Biol. 42(10), 1971–1979 (1997). [CrossRef] [PubMed]
- R. Juškattis, T. Wilson, and T. F. Watson, “Real-time white light reflection confocal microscopy using a fibre-optic bundle,” Scanning 19(1), 15–19 (1997). [CrossRef]
Cited By |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.
Related Journal Articles 
- Triangulation Method for Determining Capillary Blood Flow and Physical Characteristics of the Skin (AO)
- Imaging needle for optical coherence tomography (OL)
- Non-invasive optical mapping of the piglet brain in real time (OE)
- Instrumentation and Calibration Protocol for Imaging Dynamic Features in Dense-Scattering Media by Optical Tomography (AO)
- Cancellation of Coherent Artifacts in Optical Coherence Tomography Imaging (AO)
Related Conference Papers 
- The development of a 32-channel time-resolved optical tomography system
- Optical low-coherence tomography using an injection-seeded optical amplifier and a high-speed A-scan rotating plate technique
- First Adaptive Optics Images with the Upgraded Quinze-Vingts Hospital Retinal Imager
- Compact Semiconductor Bioluminescence Bio-sensors
- Dual-Wavelength NIR/SWIR Vein Imaging
- Firefox 11+
- Google Chrome 17+
- Internet Explorer 9+
- Safari 5+




OSA is a member of 