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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 825–847

Image analysis for classification of dysplasia in Barrett’s esophagus using endoscopic optical coherence tomography

Xin Qi, Yinsheng Pan, Michael V. Sivak, Jr., Joseph E. Willis, Gerard Isenberg, and Andrew M. Rollins  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 3, pp. 825-847 (2010)

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Barrett’s esophagus (BE) and associated adenocarcinoma have emerged as a major health care problem. Endoscopic optical coherence tomography is a microscopic sub-surface imaging technology that has been shown to differentiate tissue layers of the gastrointestinal wall and identify dysplasia in the mucosa, and is proposed as a surveillance tool to aid in management of BE. In this work a computer-aided diagnosis (CAD) system has been demonstrated for classification of dysplasia in Barrett’s esophagus using EOCT. The system is composed of four modules: region of interest segmentation, dysplasia-related image feature extraction, feature selection, and site classification and validation. Multiple feature extraction and classification methods were evaluated and the process of developing the CAD system is described in detail. Use of multiple EOCT images to classify a single site was also investigated. A total of 96 EOCT image-biopsy pairs (63 non-dysplastic, 26 low-grade and 7 high-grade dysplastic biopsy sites) from a previously described clinical study were analyzed using the CAD system, yielding an accuracy of 84% for classification of non-dysplastic vs. dysplastic BE tissue. The results motivate continued development of CAD to potentially enable EOCT surveillance of large surface areas of Barrett’s mucosa to identify dysplasia.

© 2010 OSA

OCIS Codes
(100.2960) Image processing : Image analysis
(110.4500) Imaging systems : Optical coherence tomography
(170.2150) Medical optics and biotechnology : Endoscopic imaging

ToC Category:
Optical Coherence Tomography

Original Manuscript: August 2, 2010
Revised Manuscript: September 7, 2010
Manuscript Accepted: September 7, 2010
Published: September 9, 2010

Xin Qi, Yinsheng Pan, Michael V. Sivak, Joseph E. Willis, Gerard Isenberg, and Andrew M. Rollins, "Image analysis for classification of dysplasia in Barrett’s esophagus using endoscopic optical coherence tomography," Biomed. Opt. Express 1, 825-847 (2010)

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