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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 902–910

Sentinel lymph node detection by an optical method using scattered photons

Franklin Tellier, Rasata Ravelo, Hervé Simon, Renée Chabrier, Jérôme Steibel, and Patrick Poulet  »View Author Affiliations

Biomedical Optics Express, Vol. 1, Issue 3, pp. 902-910 (2010)

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We present a new near infrared optical probe for the sentinel lymph node detection, based on the recording of scattered photons. A two wavelengths setup was developed to improve the detection threshold of an injected dye: the Patent Blue V dye. The method used consists in modulating each laser diode at a given frequency. A Fast Fourier Transform of the recorded signal separates both components. The signal amplitudes are used to compute relative Patent Blue V concentration. Results on the probe using phantoms model and small animal experimentation exhibit a sensitivity threshold of 3.2 µmol/L, which is thirty fold better than the eye visible threshold.

© 2010 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: June 1, 2010
Revised Manuscript: September 10, 2010
Manuscript Accepted: September 10, 2010
Published: September 14, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Franklin Tellier, Rasata Ravelo, Hervé Simon, Renée Chabrier, Jérôme Steibel, and Patrick Poulet, "Sentinel lymph node detection by an optical method using scattered photons," Biomed. Opt. Express 1, 902-910 (2010)

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