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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 1, Iss. 3 — Oct. 1, 2010
  • pp: 902–910

Sentinel lymph node detection by an optical method using scattered photons

Franklin Tellier, Rasata Ravelo, Hervé Simon, Renée Chabrier, Jérôme Steibel, and Patrick Poulet  »View Author Affiliations


Biomedical Optics Express, Vol. 1, Issue 3, pp. 902-910 (2010)
http://dx.doi.org/10.1364/BOE.1.000902


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Abstract

We present a new near infrared optical probe for the sentinel lymph node detection, based on the recording of scattered photons. A two wavelengths setup was developed to improve the detection threshold of an injected dye: the Patent Blue V dye. The method used consists in modulating each laser diode at a given frequency. A Fast Fourier Transform of the recorded signal separates both components. The signal amplitudes are used to compute relative Patent Blue V concentration. Results on the probe using phantoms model and small animal experimentation exhibit a sensitivity threshold of 3.2 µmol/L, which is thirty fold better than the eye visible threshold.

© 2010 OSA

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: June 1, 2010
Revised Manuscript: September 10, 2010
Manuscript Accepted: September 10, 2010
Published: September 14, 2010

Virtual Issues
Optical Imaging and Spectroscopy (2010) Biomedical Optics Express

Citation
Franklin Tellier, Rasata Ravelo, Hervé Simon, Renée Chabrier, Jérôme Steibel, and Patrick Poulet, "Sentinel lymph node detection by an optical method using scattered photons," Biomed. Opt. Express 1, 902-910 (2010)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-1-3-902


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References

  1. E. A. Gould, T. Winship, P. H. Philbin, and H. H. Kerr, “Observations on a “sentinel node” in cancer of the parotid,” Cancer 13(1), 77–78 (1960). [CrossRef] [PubMed]
  2. R. M. Cabanas, “An approach for the treatment of penile carcinoma,” Cancer 39(2), 456–466 (1977). [CrossRef] [PubMed]
  3. D. N. Krag, D. L. Weaver, J. C. Alex, and J. T. Fairbank, “Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe,” Surg. Oncol. 2(6), 335–340 (1993). [CrossRef] [PubMed]
  4. A. E. Giuliano, D. M. Kirgan, J. M. Guenther, and D. L. Morton, “Lymphatic mapping and sentinel lymphadenectomy for breast cancer,” Ann. Surg. 220(3), 391–401 (1994). [CrossRef] [PubMed]
  5. M. Garcia-Manero, B. Olartecoechea, and P. Royo, “Different injection sites of radionuclide for sentinel lymph node detection in breast cancer: single institution experience,” Eur. J. Obstet. Gynecol. Reprod. Biol. 06.024 (2010). [PubMed]
  6. M. P. Schijven, A. J. J. M. Vingerhoets, H. J. T. Rutten, G. A. P. Nieuwenhuijzen, R. M. H. Roumen, M. E. van Bussel, and A. C. Voogd, “Comparison of morbidity between axillary lymph node dissection and sentinel node biopsy,” Eur. J. Surg. Oncol. 29(4), 341–350 (2003). [CrossRef] [PubMed]
  7. T. Buckle, A. C. van Leeuwen, P. T. K. Chin, H. Janssen, S. H. Muller, J. Jonkers, and F. W. B. van Leeuwen, “A self-assembled multimodal complex for combined pre- and intraoperative imaging of the sentinel lymph node,” Nanotechnology 21(35), 355101 (2010). [CrossRef] [PubMed]
  8. D. J. Park, H. H. Kim, Y. S. Park, H. S. Lee, W. W. Lee, H.-J. Lee, and H.-K. Yang, “Simultaneous indocyanine green and 99mTc-Antimoony sulfur colloid-guided laparoscopic sentinel basin dissection for gastric cancer,” Ann. Surg. Oncol. (2010), doi:. [CrossRef] [PubMed]
  9. K. H. Song, C. Kim, K. Maslov, and L. V. Wang, “Noninvasive in vivo spectroscopic nanorod-contrast photoacoustic mapping of sentinel lymph nodes,” Eur. J. Radiol. 70(2), 227–231 (2009). [CrossRef] [PubMed]
  10. D. Pan, M. Pramanik, A. Senpan, S. Ghosh, S. A. Wickline, L. V. Wang, and G. M. Lanza, “Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons,” Biomaterials 31(14), 4088–4093 (2010). [CrossRef] [PubMed]
  11. C. Zhang, S. Wang, J. Xiao, X. Tan, Y. Zhu, Y. Su, T. Cheng, and C. Shi, “Sentinel lymph node mapping by a near-infrared fluorescent heptamethine dye,” Biomaterials 31(7), 1911–1917 (2010). [CrossRef] [PubMed]
  12. P. Wunderbaldinger, K. Turetschek, and C. Bremer, “Near-infrared fluorescence imaging of lymph nodes using a new enzyme sensing activatable macromolecular optical probe,” Eur. Radiol. 13(9), 2206–2211 (2003). [CrossRef] [PubMed]
  13. M. Chu and Y. Wan, “Sentinel lymph node mapping using near-infrared fluorescent methylene blue,” J. Biosci. Bioeng. 107(4), 455–459 (2009). [CrossRef] [PubMed]
  14. T. Hojo, T. Nagao, M. Kikuyama, S. Akashi, and T. Kinoshita, “Evaluation of sentinel node biopsy by combined fluorescent and dye method and lymph flow for breast cancer,” Breast 19(3), 210–213 (2010). [CrossRef] [PubMed]
  15. C. Hirche, D. Murawa, Z. Mohr, S. Kneif, and M. Hünerbein, “ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer,” Breast Cancer Res. Treat. 121(2), 373–378 (2010). [CrossRef] [PubMed]
  16. D. W. Newton, P. J. Breen, D. E. Brown, J. F. Mackie, and R. B. Kluza, “Physicochemical characteristics of patent blue violet dye,” J. Pharm. Sci. 70(2), 122–127 (1981). [CrossRef] [PubMed]
  17. D. Contini, F. Martelli, and G. Zaccanti, “Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory,” Appl. Opt. 36(19), 4587–4599 (1997). [CrossRef] [PubMed]
  18. S. T. Flock, S. L. Jacques, B. C. Wilson, W. M. Star, and M. J. C. van Gemert, “Optical properties of Intralipid: a phantom medium for light propagation studies,” Lasers Surg. Med. 12(5), 510–519 (1992). [CrossRef] [PubMed]
  19. J. Moblay, and T. Vo-Dinh, Biomedical photonics handbook, (CRC Press, 2003), Chap. 2.
  20. I. J. Namaer, J. Steibel, P. Poulet, J. P. Armspach, Y. Mauss, and J. Chambron, “In vivo dynamic MR imaging of MBP-induced acute experimental allergic encephalomyelitis in Lewis rat,” Magn. Reson. Med. 24(2), 325–334 (1992). [CrossRef] [PubMed]
  21. N. L. Tilney, “Patterns of lymphatic drainage in the adult laboratory rat,” J. Anat. 109(Pt 3), 369–383 (1971). [PubMed]
  22. C. E. Metz, “Basic principles of ROC analysis,” Semin. Nucl. Med. 8(4), 283–298 (1978). [CrossRef] [PubMed]

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